methyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-3-azetidinecarboxylate

Base Information

Chemical Name:methyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-3-azetidinecarboxylate
CAS No.:1344997-37-0
Molecular Formula:C₂₆H₃₀ClN₃O₃S
Molecular Weight:500.062
Hs Code.:

Synonyms:methyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-3-azetidinecarboxylate

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Chemical Property of methyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-3-azetidinecarboxylate

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Technology Process of methyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-3-azetidinecarboxylate

There total 5 articles about methyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-3-azetidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1344997-35-8
[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]acetaldehyde

: 343238-58-4
methyl azetidine-3-carboxylate

: 1344997-37-0
methyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-3-azetidinecarboxylate

Guidance literature:: [3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]acetaldehyde; methyl azetidine-3-carboxylate; With sodium acetate; acetic acid; In methanol; at 20 ℃; for 0.166667h;

With sodium tris(acetoxy)borohydride; In dichloromethane;

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1344997-37-0
methyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-3-azetidinecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 3 h / 75 °C

1.2: Cooling with ice

2.1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 3 h / 20 °C

3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.17 h / 120 °C / Microwave irradiation; Sealed vessel; Inert atmosphere

4.1: hydrogenchloride; water / tetrahydrofuran / 4 h / 70 °C / Inert atmosphere

5.1: sodium acetate; acetic acid / methanol / 0.17 h / 20 °C

With hydrogenchloride; potassium phosphate; tert.-butylnitrite; water; sodium acetate; acetic acid; copper(ll) bromide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; 3.1: Suzuki Coupling;

Reference yield:

: 1258440-61-7
5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-amine

: 1344997-37-0
methyl 1-{2-[3-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2-ethylphenyl]ethyl}-3-azetidinecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 3 h / 20 °C

2: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 0.17 h / 120 °C / Microwave irradiation; Sealed vessel; Inert atmosphere

3: hydrogenchloride; water / tetrahydrofuran / 4 h / 70 °C / Inert atmosphere

4: sodium acetate; acetic acid / methanol / 0.17 h / 20 °C

With hydrogenchloride; potassium phosphate; tert.-butylnitrite; water; sodium acetate; acetic acid; copper(ll) bromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile; 2: Suzuki Coupling;