N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]cyclopropanamine mesylate

Base Information

Chemical Name:N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]cyclopropanamine mesylate
CAS No.:1194491-85-4
Molecular Formula:CH₄O₃S*C₁₅H₂₂BrNO
Molecular Weight:408.357
Hs Code.:

Synonyms:N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]cyclopropanamine mesylate

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Chemical Property of N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]cyclopropanamine mesylate

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Technology Process of N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]cyclopropanamine mesylate

There total 9 articles about N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]cyclopropanamine mesylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-75-2,98527-29-8
methanesulfonic acid

: 1194488-55-5
N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]cyclopropanamine

: 1194491-85-4
N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]cyclopropanamine mesylate

Guidance literature:: In tetrahydrofuran; tert-butyl methyl ether; Isopropyl acetate; at 24.8 ℃; for 4h; Inert atmosphere; Large scale reaction;
DOI:10.1021/op2001063

Reference yield:

: 1229245-18-4
3-bromo-N-cyclopropyl-5-(3-methoxyprop-1-yn-1-yl)-4-methylbenzamide

: 1194491-85-4
N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]cyclopropanamine mesylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: platinum(IV) oxide; hydrogen; triethylamine / toluene / 4.5 h / 20 - 35 °C / 2052.96 Torr / Autoclave; Large scale reaction

2.1: sodium tetrahydroborate; boron trifluoride-tetrahydrofuran complex / tetrahydrofuran / 21.5 h / 19.8 - 35 °C / Inert atmosphere; Large scale reaction

2.2: 4 h / 20 - 50 °C / Inert atmosphere; Large scale reaction

2.3: pH 14 / Large scale reaction

3.1: tetrahydrofuran; tert-butyl methyl ether; Isopropyl acetate / 4 h / 24.8 °C / Inert atmosphere; Large scale reaction

With platinum(IV) oxide; sodium tetrahydroborate; boron trifluoride-tetrahydrofuran complex; hydrogen; triethylamine; In tetrahydrofuran; tert-butyl methyl ether; Isopropyl acetate; toluene;
DOI:10.1021/op2001063

Reference yield:

: 1229245-19-5
3-bromo-5-(3-methoxyprop-1-yn-1-yl)-4-methylbenzoic acid

: 1194491-85-4
N-[3-bromo-5-(3-methoxypropyl)-4-methylbenzyl]cyclopropanamine mesylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine / tetrahydrofuran; ethyl acetate / 1.75 h / 9 - 19 °C / Inert atmosphere; Large scale reaction

2.1: platinum(IV) oxide; hydrogen; triethylamine / toluene / 4.5 h / 20 - 35 °C / 2052.96 Torr / Autoclave; Large scale reaction

3.1: sodium tetrahydroborate; boron trifluoride-tetrahydrofuran complex / tetrahydrofuran / 21.5 h / 19.8 - 35 °C / Inert atmosphere; Large scale reaction

3.2: 4 h / 20 - 50 °C / Inert atmosphere; Large scale reaction

3.3: pH 14 / Large scale reaction

4.1: tetrahydrofuran; tert-butyl methyl ether; Isopropyl acetate / 4 h / 24.8 °C / Inert atmosphere; Large scale reaction

With platinum(IV) oxide; sodium tetrahydroborate; boron trifluoride-tetrahydrofuran complex; hydrogen; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tert-butyl methyl ether; Isopropyl acetate; ethyl acetate; toluene;
DOI:10.1021/op2001063