Bis(4-bromomethylphenyl)methane

Base Information

• Chemical Name: Bis(4-bromomethylphenyl)methane
• CAS No.: 16980-01-1
• Molecular Formula: C15H14 Br2
• Molecular Weight: 354.084
• Hs Code.: 2903999090
• DSSTox Substance ID: DTXSID90497521
• Nikkaji Number: J669.687B
• Mol file: 16980-01-1.mol

Synonyms:BIS(4-BROMOMETHYLPHENYL)METHANE;16980-01-1;1-(bromomethyl)-4-[[4-(bromomethyl)phenyl]methyl]benzene;1,1'-Methylenebis[4-(bromomethyl)benzene];bis[4-(bromomethyl)phenyl]methane;SCHEMBL5885289;DTXSID90497521;AKOS025296250;F72060

Chemical Property of Bis(4-bromomethylphenyl)methane

Chemical Property:

• PSA: 0.00000
• LogP: 5.06720
• XLogP3: 5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 0
• Rotatable Bond Count: 4
• Exact Mass: 353.94418
• Heavy Atom Count: 17
• Complexity: 179

Purity/Quality:

99% ^*data from raw suppliers

Bis(4-bromomethylphenyl)methane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1CC2=CC=C(C=C2)CBr)CBr

Technology Process of Bis(4-bromomethylphenyl)methane

There total 6 articles about Bis(4-bromomethylphenyl)methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

Diphenylmethane (101-81-5) → bis(4-bromomethylphenyl)methane (16980-01-1)

Guidance literature:

With phosphoric acid; hydrogen bromide; In acetic acid; for 3h;

Reference yield: 62.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Diphenylmethane (101-81-5) → bis(4-bromomethylphenyl)methane (16980-01-1)

Guidance literature:

With hydrogen bromide; zinc dibromide; In acetic acid; at 95 ℃;

DOI:10.1039/b806958a

Reference yield:

4,4'-Bis-methoxymethyl benzophenone (90021-26-4) → bis(4-bromomethylphenyl)methane (16980-01-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / KOH; hydrazine monohydrate / bis-(2-hydroxy-ethyl) ether / 0.33 h / 130 °C / microwave irradiation

2: 87 percent / Me₃SiBr / chlorobenzene / 4 h / 75 °C

With potassium hydroxide; trimethylsilyl bromide; hydrazine hydrate; In chlorobenzene; diethylene glycol; 1: Wolff-Kishner reaction;

DOI:10.1016/j.tet.2005.09.106

upstream raw materials:

formaldehyd

Diphenylmethane

4,4'-Bis-methoxymethyl benzophenone

1-bromo-4-methoxymethylbenzene

Downstream raw materials:

bis-(4-piperidinomethyl-phenyl)-methane

{4-[4-(Dimethoxy-phosphorylmethyl)-benzyl]-benzyl}-phosphonic acid dimethyl ester

N₁-{6-[(mesitylsulfonyl)(4-{4-[((mesitylsulfonyl){6-[(mesitylsulfonyl)(2-methoxybenzyl)amino]hexyl}amino)methyl]benzyl}benzyl)amino]hexyl}-N₁-(2-methoxybenzyl)-2,4,6-trimethyl-1-benzenesulfonamide

CrCH₂C₆H₄CH₂C₆H₄CH₂Cr⁽⁴⁺⁾*4ClO₄^(1-)