2-[2-fluoro-4-(2-{(1S,2R)-2-[1-[5-(methoxymethyl)pyrimidine-2-yl]piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetohydrazide

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Chemical Name:2-[2-fluoro-4-(2-{(1S,2R)-2-[1-[5-(methoxymethyl)pyrimidine-2-yl]piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetohydrazide
CAS No.:1437779-20-8
Molecular Formula:C₂₄H₃₂FN₅O₃
Molecular Weight:457.548
Hs Code.:

Synonyms:2-[2-fluoro-4-(2-{(1S,2R)-2-[1-[5-(methoxymethyl)pyrimidine-2-yl]piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetohydrazide

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Chemical Property of 2-[2-fluoro-4-(2-{(1S,2R)-2-[1-[5-(methoxymethyl)pyrimidine-2-yl]piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetohydrazide

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Technology Process of 2-[2-fluoro-4-(2-{(1S,2R)-2-[1-[5-(methoxymethyl)pyrimidine-2-yl]piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetohydrazide

There total 19 articles about 2-[2-fluoro-4-(2-{(1S,2R)-2-[1-[5-(methoxymethyl)pyrimidine-2-yl]piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68886-07-7
(2-fluoro-4-hydroxylphenyl)acetic acid

: 1437779-20-8
2-[2-fluoro-4-(2-{(1S,2R)-2-[1-[5-(methoxymethyl)pyrimidine-2-yl]piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / Reflux

2.1: di-tert-butyl-diazodicarboxylate / dichloromethane / 3 h / 20 °C

3.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

3.2: pH 4

4.1: triethylamine; methyl chloroformate / tetrahydrofuran / 0.5 h / -10 °C

4.2: 20 °C

With di-tert-butyl-diazodicarboxylate; sulfuric acid; water; triethylamine; methyl chloroformate; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 1437778-94-3
{2-fluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid

: 1437779-20-8
2-[2-fluoro-4-(2-{(1S,2R)-2-[1-[5-(methoxymethyl)pyrimidine-2-yl]piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetohydrazide

Guidance literature:: {2-fluoro-4-[2-((1S,2R)-2-{1-[5-(methoxymethyl)pyrimidin-2-yl]piperidin-4-yl}cyclopropyl)ethoxy]phenyl}acetic acid; With triethylamine; methyl chloroformate; In tetrahydrofuran; at -10 ℃; for 0.5h;

With hydrazine hydrate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: cis-tert-butyl 4-[2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate

: 1437779-20-8
2-[2-fluoro-4-(2-{(1S,2R)-2-[1-[5-(methoxymethyl)pyrimidine-2-yl]piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetohydrazide

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogenchloride / 2 h / 20 °C

2.1: triethylamine / ethyl acetate / 4 h / Reflux

3.1: dipotassium hydrogenphosphate; sodium carbonate / water; dimethyl sulfoxide; methanol / 7 h / 21 - 25 °C / pH 7 - 8 / Enzymatic reaction

3.2: 0.5 h / 40 °C / pH Ca_. 14

4.1: palladium on carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr

5.1: potassium carbonate / N,N-dimethyl-formamide

6.1: di-tert-butyl-diazodicarboxylate / dichloromethane / 3 h / 20 °C

7.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

7.2: pH 4

8.1: triethylamine; methyl chloroformate / tetrahydrofuran / 0.5 h / -10 °C

8.2: 20 °C

With hydrogenchloride; dipotassium hydrogenphosphate; di-tert-butyl-diazodicarboxylate; palladium on carbon; water; hydrogen; sodium carbonate; potassium carbonate; triethylamine; methyl chloroformate; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;