2-[4-((1R,2S)-2-{2-[3-fluoro-4-(1,3,4-thiadiazol-2-ylmethyl)phenoxy]ethyl}cyclopropyl)piperidin-1-yl]-5-(methoxymethyl)pyrimidine

Base Information

Chemical Name:2-[4-((1R,2S)-2-{2-[3-fluoro-4-(1,3,4-thiadiazol-2-ylmethyl)phenoxy]ethyl}cyclopropyl)piperidin-1-yl]-5-(methoxymethyl)pyrimidine
CAS No.:1437778-75-0
Molecular Formula:C₂₅H₃₀FN₅O₂S
Molecular Weight:483.61
Hs Code.:

Synonyms:2-[4-((1R,2S)-2-{2-[3-fluoro-4-(1,3,4-thiadiazol-2-ylmethyl)phenoxy]ethyl}cyclopropyl)piperidin-1-yl]-5-(methoxymethyl)pyrimidine

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Chemical Property of 2-[4-((1R,2S)-2-{2-[3-fluoro-4-(1,3,4-thiadiazol-2-ylmethyl)phenoxy]ethyl}cyclopropyl)piperidin-1-yl]-5-(methoxymethyl)pyrimidine

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Technology Process of 2-[4-((1R,2S)-2-{2-[3-fluoro-4-(1,3,4-thiadiazol-2-ylmethyl)phenoxy]ethyl}cyclopropyl)piperidin-1-yl]-5-(methoxymethyl)pyrimidine

There total 20 articles about 2-[4-((1R,2S)-2-{2-[3-fluoro-4-(1,3,4-thiadiazol-2-ylmethyl)phenoxy]ethyl}cyclopropyl)piperidin-1-yl]-5-(methoxymethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68886-07-7
(2-fluoro-4-hydroxylphenyl)acetic acid

: 1437778-75-0
2-[4-((1R,2S)-2-{2-[3-fluoro-4-(1,3,4-thiadiazol-2-ylmethyl)phenoxy]ethyl}cyclopropyl)piperidin-1-yl]-5-(methoxymethyl)pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / Reflux

2.1: di-tert-butyl-diazodicarboxylate / dichloromethane / 3 h / 20 °C

3.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

3.2: pH 4

4.1: triethylamine; methyl chloroformate / tetrahydrofuran / 0.5 h / -10 °C

4.2: 20 °C

5.1: 20 °C

5.2: 3 h / 100 °C

With di-tert-butyl-diazodicarboxylate; sulfuric acid; water; triethylamine; methyl chloroformate; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 64-18-6
formic acid

: 1437779-20-8
2-[2-fluoro-4-(2-{(1S,2R)-2-[1-[5-(methoxymethyl)pyrimidine-2-yl]piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetohydrazide

: 1437778-75-0
2-[4-((1R,2S)-2-{2-[3-fluoro-4-(1,3,4-thiadiazol-2-ylmethyl)phenoxy]ethyl}cyclopropyl)piperidin-1-yl]-5-(methoxymethyl)pyrimidine

Guidance literature:: formic acid; 2-[2-fluoro-4-(2-{(1S,2R)-2-[1-[5-(methoxymethyl)pyrimidine-2-yl]piperidin-4-yl]cyclopropyl}ethoxy)phenyl]acetohydrazide; at 20 ℃;

With Lawessons reagent; at 100 ℃; for 3h;

Reference yield:

: cis-tert-butyl 4-[2-(2-hydroxyethyl)cyclopropyl]piperidine-1-carboxylate

: 1437778-75-0
2-[4-((1R,2S)-2-{2-[3-fluoro-4-(1,3,4-thiadiazol-2-ylmethyl)phenoxy]ethyl}cyclopropyl)piperidin-1-yl]-5-(methoxymethyl)pyrimidine

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride / 2 h / 20 °C

2.1: triethylamine / ethyl acetate / 4 h / Reflux

3.1: dipotassium hydrogenphosphate; sodium carbonate / water; dimethyl sulfoxide; methanol / 7 h / 21 - 25 °C / pH 7 - 8 / Enzymatic reaction

3.2: 0.5 h / 40 °C / pH Ca_. 14

4.1: palladium on carbon; hydrogen / methanol / 48 h / 20 °C / 760.05 Torr

5.1: potassium carbonate / N,N-dimethyl-formamide

6.1: di-tert-butyl-diazodicarboxylate / dichloromethane / 3 h / 20 °C

7.1: lithium hydroxide; water / tetrahydrofuran; methanol / 20 °C

7.2: pH 4

8.1: triethylamine; methyl chloroformate / tetrahydrofuran / 0.5 h / -10 °C

8.2: 20 °C

9.1: 20 °C

9.2: 3 h / 100 °C

With hydrogenchloride; dipotassium hydrogenphosphate; di-tert-butyl-diazodicarboxylate; palladium on carbon; water; hydrogen; sodium carbonate; potassium carbonate; triethylamine; methyl chloroformate; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;