methanesulfonic acid (S)-diethylcarbamoyl-phenyl-methyl ester

Base Information

• Chemical Name: methanesulfonic acid (S)-diethylcarbamoyl-phenyl-methyl ester
• CAS No.: 1094873-21-8
• Molecular Formula: C₁₃H₁₉NO₄S
• Molecular Weight: 285.364
• Mol file: 1094873-21-8.mol

Synonyms:methanesulfonic acid (S)-diethylcarbamoyl-phenyl-methyl ester

Chemical Property of methanesulfonic acid (S)-diethylcarbamoyl-phenyl-methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methanesulfonic acid (S)-diethylcarbamoyl-phenyl-methyl ester

There total 3 articles about methanesulfonic acid (S)-diethylcarbamoyl-phenyl-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-diethyl-(2S)-2-hydroxy-2-phenyl-acetamide (65309-15-1,65197-96-8) + methanesulfonyl chloride (124-63-0) → methanesulfonic acid (S)-diethylcarbamoyl-phenyl-methyl ester (1094873-21-8)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 1h;

Reference yield:

(S)-hydroxy-phenyl-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester (97906-37-1) → methanesulfonic acid (S)-diethylcarbamoyl-phenyl-methyl ester (1094873-21-8)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran; water / 16 h / 20 °C

2: triethylamine / dichloromethane / 0 °C

With triethylamine; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/j.bmcl.2011.06.136

Reference yield:

(S)-Mandelic acid (17199-29-0) → methanesulfonic acid (S)-diethylcarbamoyl-phenyl-methyl ester (1094873-21-8)

Guidance literature:

Multi-step reaction with 3 steps

1: dicyclohexyl-carbodiimide / ethyl acetate / 4 h / 20 °C

2: tetrahydrofuran; water / 16 h / 20 °C

3: triethylamine / dichloromethane / 0 °C

With triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; water; ethyl acetate;

DOI:10.1016/j.bmcl.2011.06.136

upstream raw materials:

N,N-diethyl-(2S)-2-hydroxy-2-phenyl-acetamide

methanesulfonyl chloride

(S)-Mandelic acid

(S)-hydroxy-phenyl-acetic acid 2,5-dioxo-pyrrolidin-1-yl ester

Downstream raw materials:

(-)-JNJ-31020028