97906-37-1

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 17199-29-0 (S)-Mandelic acid 
• 98-86-2 acetophenone 
• 611-73-4 Benzoylformic acid 

Downstream Products

• 79043-43-9 (S)-2-hydroxy-2-phenyl-N,N-dimethylacetamide 
• 201350-77-8 (S)-2-Hydroxy-N-methyl-2-phenyl-N-piperidin-1-yl-acetamide 
• 65309-15-1 N,N-diethyl-(2S)-2-hydroxy-2-phenyl-acetamide 
• 1094873-21-8 methanesulfonic acid (S)-diethylcarbamoyl-phenyl-methyl ester 
• 1094873-17-2 (-)-JNJ-31020028 
• 97850-68-5 Methanesulfonic acid (S)-dimethylcarbamoyl-phenyl-methyl ester 
• 201350-79-0 (S)-N-((S)-2-Allyl-piperidin-1-yl)-2-hydroxy-N-methyl-2-phenyl-acetamide 

Relevant academic research and scientific papers

Chiral Amplification by Self-Assembly of Neutral Luminescent Platinum(II) Complexes

Two novel enantiomerically pure chiral ligands and the corresponding neutral PtII complexes have been synthetized and characterized. The self-assembly properties of the complexes have been investigated using different morphological and photophysical techniques. The two enantiomeric complexes, 4 a and 4 b, show high tendency to self-assemble into chiral supramolecular aggregates with right (P) and left-handed (M) helical configurations, respectively, as proven by SEM and absorption circular dichroism. The formation of such organized structures is driven by the formation of metallophilic and π–π interactions between spatially close Pt complexes with an enhancement of the chiro-optical properties in the solid state.

The Synthesis of Chiral α-Aryl α-Hydroxy Carboxylic Acids via RuPHOX-Ru Catalyzed Asymmetric Hydrogenation

A ruthenocenyl phosphino-oxazoline-ruthenium complex (RuPHOX?Ru) catalyzed asymmetric hydrogenation of α-aryl keto acids has been successfully developed, affording the corresponding chiral α-aryl α-hydroxy carboxylic acids in high yields and with up to 97% ee. The reaction could be performed on a gram scale with a relatively low catalyst loading (up to 5000 S/C) and the resulting products can be transformed to several chiral building blocks, biologically active compounds and chiral drugs. (Figure presented.).

The discovery and synthesis of JNJ 31020028, a small molecule antagonist of the Neuropeptide y Y2 receptor

A series of small molecules based on a chemotype identified from our compound collection were synthesized and tested for binding affinity (IC 50) at the human Neuropeptide Y Y2 receptor (NPY Y 2). Six of the 23 analogs tes

PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR

The present invention is directed to piperazinyl derivatives useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and / or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.

Catalytic asymmetric acylation of (silyloxy)nitrile anions

An enantiopure (salen)aluminum alkoxide complex catalyzes the asymmetric coupling of acylsilanes and cyanoformate esters [Eq. (1), R = Bn, Et]. The reactions afford unsymmetrical, fully protected malonic acid derivatives that may be elaborated to nonnatural β-amino acid derivatives, and represent the first asymmetric catalytic reactions involving protected cyanohydrin anions.

ON CARBONYL PARTICIPATION IN THE SOLVOLYSES OF α-KETO MESYLATES

α-amido mesylates generally solvolyze giving α-keto cations, bypassing cyclic ions derived from carbonyl (kΔ) participation.A possible exception is the N,N-dimethylamido mesylate derived from (S)-mandelic acid in trifluoroacetic acid which gives a small amount (9percent) of retained product.