((4S,5S)-5-{2-[(S)-2-Benzyloxy-3-(4-methoxy-benzyloxy)-propyl]-[1,3]dithian-2-yl}-3-methoxy-4-methyl-hex-1-ynyl)-trimethyl-silane

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Chemical Name:((4S,5S)-5-{2-[(S)-2-Benzyloxy-3-(4-methoxy-benzyloxy)-propyl]-[1,3]dithian-2-yl}-3-methoxy-4-methyl-hex-1-ynyl)-trimethyl-silane
CAS No.:617673-31-1
Molecular Formula:C₃₃H₄₈O₄S₂Si
Molecular Weight:600.959
Hs Code.:

Synonyms:((4S,5S)-5-{2-[(S)-2-Benzyloxy-3-(4-methoxy-benzyloxy)-propyl]-[1,3]dithian-2-yl}-3-methoxy-4-methyl-hex-1-ynyl)-trimethyl-silane

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Chemical Property of ((4S,5S)-5-{2-[(S)-2-Benzyloxy-3-(4-methoxy-benzyloxy)-propyl]-[1,3]dithian-2-yl}-3-methoxy-4-methyl-hex-1-ynyl)-trimethyl-silane

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Technology Process of ((4S,5S)-5-{2-[(S)-2-Benzyloxy-3-(4-methoxy-benzyloxy)-propyl]-[1,3]dithian-2-yl}-3-methoxy-4-methyl-hex-1-ynyl)-trimethyl-silane

There total 4 articles about ((4S,5S)-5-{2-[(S)-2-Benzyloxy-3-(4-methoxy-benzyloxy)-propyl]-[1,3]dithian-2-yl}-3-methoxy-4-methyl-hex-1-ynyl)-trimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1066-54-2
trimethylsilylacetylene

: 552890-64-9
(2S,3S)-3-{2-[(S)-2-Benzyloxy-3-(4-methoxy-benzyloxy)-propyl]-[1,3]dithian-2-yl}-2-methyl-butyraldehyde

: 74-88-4
methyl iodide

: 617673-31-1
((4S,5S)-5-{2-[(S)-2-Benzyloxy-3-(4-methoxy-benzyloxy)-propyl]-[1,3]dithian-2-yl}-3-methoxy-4-methyl-hex-1-ynyl)-trimethyl-silane

Guidance literature:: trimethylsilylacetylene; With tert.-butyl lithium; In tetrahydrofuran; hexane; at 0 ℃; for 0.25h;

(2S,3S)-3-{2-[(S)-2-Benzyloxy-3-(4-methoxy-benzyloxy)-propyl]-[1,3]dithian-2-yl}-2-methyl-butyraldehyde; In tetrahydrofuran; hexane; at 0 ℃; for 0.333333h;

methyl iodide; In tetrahydrofuran; hexane; at 20 ℃; for 2.5h;
DOI:10.1016/S0040-4020(03)00873-1

Reference yield:

: 552890-45-6
(2R,3S,4S,5S)-1-Benzyloxy-5-{2-[(S)-2-benzyloxy-3-(4-methoxy-benzyloxy)-propyl]-[1,3]dithian-2-yl}-4-methyl-hexane-2,3-diol

: 617673-31-1
((4S,5S)-5-{2-[(S)-2-Benzyloxy-3-(4-methoxy-benzyloxy)-propyl]-[1,3]dithian-2-yl}-3-methoxy-4-methyl-hex-1-ynyl)-trimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 99 percent / Pb(OAc)4 / CH₂Cl₂ / 1 h / 20 °C

2.1: t-BuLi / tetrahydrofuran; hexane / 0.25 h / 0 °C

2.2: tetrahydrofuran; hexane / 0.33 h / 0 °C

2.3: 89 percent / tetrahydrofuran; hexane / 2.5 h / 20 °C

With lead(IV) acetate; tert.-butyl lithium; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1016/S0040-4020(03)00873-1

Reference yield:

: 552890-64-9
(2S,3S)-3-{2-[(S)-2-Benzyloxy-3-(4-methoxy-benzyloxy)-propyl]-[1,3]dithian-2-yl}-2-methyl-butyraldehyde

: 617673-31-1
((4S,5S)-5-{2-[(S)-2-Benzyloxy-3-(4-methoxy-benzyloxy)-propyl]-[1,3]dithian-2-yl}-3-methoxy-4-methyl-hex-1-ynyl)-trimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: n-BuLi / tetrahydrofuran

2: tetrahydrofuran

With n-butyllithium; In tetrahydrofuran;
DOI:10.1055/s-2003-37533