tert-butyl N-dodecyl-3-[(RS)-1-hydroxy-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-yl]phenylcarbamate

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Chemical Name:tert-butyl N-dodecyl-3-[(RS)-1-hydroxy-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-yl]phenylcarbamate
CAS No.:1346510-95-9
Molecular Formula:C₃₀H₄₃N₃O₄
Molecular Weight:509.689
Hs Code.:

Synonyms:tert-butyl N-dodecyl-3-[(RS)-1-hydroxy-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-yl]phenylcarbamate

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Chemical Property of tert-butyl N-dodecyl-3-[(RS)-1-hydroxy-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-yl]phenylcarbamate

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Technology Process of tert-butyl N-dodecyl-3-[(RS)-1-hydroxy-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-yl]phenylcarbamate

There total 5 articles about tert-butyl N-dodecyl-3-[(RS)-1-hydroxy-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-yl]phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4664-01-1
3,4-pyridinedicarboximide

: 1346510-98-2
tert-butyl N-(3-bromophenyl)-N-dodecylcarbamate

: C₃₀H₄₃N₃O₄

: 1346510-95-9
tert-butyl N-dodecyl-3-[(RS)-1-hydroxy-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-yl]phenylcarbamate

Guidance literature:: tert-butyl N-(3-bromophenyl)-N-dodecylcarbamate; With n-butyllithium; In tetrahydrofuran; at -50 - -40 ℃; Inert atmosphere;

3,4-pyridinedicarboximide; In tetrahydrofuran; at -50 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2011.09.017

Reference yield:

: 591-19-5
m-Bromoaniline

: 1346510-95-9
tert-butyl N-dodecyl-3-[(RS)-1-hydroxy-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-yl]phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / methanol / 18 h / 50 °C

2.1: potassium tert-butylate / tetrahydrofuran / 21 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran / -50 - -40 °C / Inert atmosphere

3.2: 1 h / -50 °C / Inert atmosphere

With n-butyllithium; potassium tert-butylate; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1016/j.bmc.2011.09.017

Reference yield:

: 25216-74-4
tert-butyl (3-bromophenyl)carbamate

: 1346510-95-9
tert-butyl N-dodecyl-3-[(RS)-1-hydroxy-3-oxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridin-1-yl]phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / tetrahydrofuran / 21 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / -50 - -40 °C / Inert atmosphere

2.2: 1 h / -50 °C / Inert atmosphere

With n-butyllithium; potassium tert-butylate; In tetrahydrofuran;
DOI:10.1016/j.bmc.2011.09.017