Isopropyl (4S)-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

Chemical Name:Isopropyl (4S)-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS No.:285136-76-7
Molecular Formula:C₁₅H₁₇N₃O₅
Molecular Weight:319.317
Hs Code.:

Synonyms:Isopropyl (4S)-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Chemical Property of Isopropyl (4S)-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Technology Process of Isopropyl (4S)-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 8 articles about Isopropyl (4S)-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1161789-88-3
(2S,4S)-5-isopropoxycarbonyl-6-methyl-3-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl]-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one

: 285136-76-7
Isopropyl (4S)-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: (2S,4S)-5-isopropoxycarbonyl-6-methyl-3-[2-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-3-phenylpropionyl]-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃;

With water; Rochelle's salt; In tetrahydrofuran; Cooling;
DOI:10.1016/j.tet.2009.03.060

Reference yield: 83.0%

: 285136-74-5
Isopropyl (4S)-3-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 285136-76-7
Isopropyl (4S)-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With ammonium hydroxide; In methanol; at 45 ℃; for 48h;
DOI:10.1039/b006372j

Reference yield: 81.0%

: (S)-isopropyl-6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 285136-76-7
Isopropyl (4S)-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With ammonia; dihydrogen peroxide; In water; ethyl acetate; at 50 ℃; for 1h; optical yield given as %ee;
DOI:10.1039/c2ob25663k