Isopropyl 3-acetoxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

Chemical Name:Isopropyl 3-acetoxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS No.:285136-73-4
Molecular Formula:C₁₈H₂₁N₃O₇
Molecular Weight:391.381
Hs Code.:

Synonyms:Isopropyl 3-acetoxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Chemical Property of Isopropyl 3-acetoxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Technology Process of Isopropyl 3-acetoxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 3 articles about Isopropyl 3-acetoxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 75-36-5
acetyl chloride

: 331947-79-6
Isopropyl 3-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 285136-73-4
Isopropyl 3-acetoxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 5 ℃; for 1h;
DOI:10.1039/b006372j

Reference yield:

: 131275-78-0
Isopropyl 6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 285136-73-4
Isopropyl 3-acetoxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / aq. K₂CO₃ / ethanol / 48 h / Heating

2: 72 percent / Et₃N / tetrahydrofuran / 1 h / 0 - 5 °C

With potassium carbonate; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1039/b006372j

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 285136-73-4
Isopropyl 3-acetoxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 94 percent / polyphosphonate ester / tetrahydrofuran / 24 h / Heating

2: K₂CO₃ / H₂O; ethanol / 48 h / Heating

3: Et₃N / tetrahydrofuran / 1 h / 0 °C

With polyphosphonate ester; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; water; 1: Biginelli cyclocondensation / 2: hydroxymethylation / 3: Acetylation;
DOI:10.1016/S0957-4166(00)00081-1