Isopropyl (4S)-3-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

Chemical Name:Isopropyl (4S)-3-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS No.:285136-74-5
Molecular Formula:C₁₆H₁₉N₃O₆
Molecular Weight:349.343
Hs Code.:

Synonyms:Isopropyl (4S)-3-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Chemical Property of Isopropyl (4S)-3-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Technology Process of Isopropyl (4S)-3-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 4 articles about Isopropyl (4S)-3-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 285136-73-4
Isopropyl 3-acetoxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 285136-74-5
Isopropyl (4S)-3-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 285136-75-6
Isopropyl (4R)-3-acetoxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With Amano CE lipase; dextran; In di-isopropyl ether; at 20 ℃; for 72h; Enzymatic reaction;
DOI:10.1016/S0957-4166(00)00081-1

Reference yield:

: 131275-78-0
Isopropyl 6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 285136-74-5
Isopropyl (4S)-3-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / aq. K₂CO₃ / ethanol / 48 h / Heating

2: 72 percent / Et₃N / tetrahydrofuran / 1 h / 0 - 5 °C

3: 88 mg / Thermomyces lanuginosus lipase; dextran; phosphate buffer / diisopropyl ether / 72 h / 23 °C / pH 7

With phosphate buffer; Thermomyces lanuginosus lipase; potassium carbonate; triethylamine; dextran; In tetrahydrofuran; ethanol; di-isopropyl ether;
DOI:10.1039/b006372j

Reference yield:

: 331947-79-6
Isopropyl 3-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 285136-74-5
Isopropyl (4S)-3-hydroxymethyl-6-methyl-4-(3-nitrophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / Et₃N / tetrahydrofuran / 1 h / 0 - 5 °C

2: 88 mg / Thermomyces lanuginosus lipase; dextran; phosphate buffer / diisopropyl ether / 72 h / 23 °C / pH 7

With phosphate buffer; Thermomyces lanuginosus lipase; triethylamine; dextran; In tetrahydrofuran; di-isopropyl ether;
DOI:10.1039/b006372j