(2R,3S)-2-methyl-4-nitro-3-m-tolylbutanal

Base Information

• Chemical Name: (2R,3S)-2-methyl-4-nitro-3-m-tolylbutanal
• CAS No.: 1287234-07-4
• Molecular Formula: C₁₂H₁₅NO₃
• Molecular Weight: 221.256
• Mol file: 1287234-07-4.mol

Synonyms:(2R,3S)-2-methyl-4-nitro-3-m-tolylbutanal

Chemical Property of (2R,3S)-2-methyl-4-nitro-3-m-tolylbutanal

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (2R,3S)-2-methyl-4-nitro-3-m-tolylbutanal

There total 2 articles about (2R,3S)-2-methyl-4-nitro-3-m-tolylbutanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

propionaldehyde (123-38-6) + (E)-1-methyl-3-(2-nitrovinyl)benzene (22568-43-0) → (2R,3S)-2-methyl-4-nitro-3-m-tolylbutanal (1287234-07-4) + C12H15NO3

Guidance literature:

(E)-1-methyl-3-(2-nitrovinyl)benzene; With magnetic nanoparticles Fe₃O₄ supported on (S)-diphenylprolinoltrimethylsilyl modified polyvinylpyrrolidone; In dichloromethane; at 0 ℃; for 0.166667h;

propionaldehyde; In dichloromethane; for 12h; Overall yield = 98 %; stereoselective reaction;

DOI:10.1039/c6ra01051b

Reference yield:

1-methyl-3-(2-nitrovinyl)benzene (22568-43-0,62248-93-5) + propionaldehyde (123-38-6) → (2S,3R)-2-methyl-4-nitro-3-m-tolylbutanal + (2R,3S)-2-methyl-4-nitro-3-m-tolylbutanal (1287234-07-4) + 2-methyl-4-nitro-3-m-tolylbutanal

Guidance literature:

With magnetic nanoparticles (Fe₃O₄ coated with SiO₂)-supported (S)-diphenylprolinol trimethylsilyl ether catalyst; In water; at 20 ℃; for 72h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/adsc.201000508

Reference yield: 87.0%

di-isopropyl azodicarboxylate (2446-83-5) + (2R,3S)-2-methyl-4-nitro-3-m-tolylbutanal (1287234-07-4) → diisopropyl 1-[(2S,3S)-2-methyl-4-nitro-1-oxo-3-(3-methylphenyl)butan-2-yl]hydrazine-1,2-dicarboxylate

Guidance literature:

di-isopropyl azodicarboxylate; (2R,3S)-2-methyl-4-nitro-3-m-tolylbutanal; In chloroform; at 20 ℃; for 0.166667h;

With trifluoroacetic acid; In chloroform; at 20 ℃; for 90h; stereoselective reaction;

DOI:10.1039/c6ra16217g

upstream raw materials:

1-methyl-3-(2-nitrovinyl)benzene

propionaldehyde

(E)-1-methyl-3-(2-nitrovinyl)benzene