Technology Process of 1-(3-chloro-5-(trifluoromethyl)phenyl)ethanol
There total 6 articles about 1-(3-chloro-5-(trifluoromethyl)phenyl)ethanol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-chloro-5-(trifluoromethyl)benzaldehyde; methylmagnesium bromide;
In
tetrahydrofuran; diethyl ether;
at -10 ℃;
With
ammonium chloride;
In
tetrahydrofuran; diethyl ether;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: acetyl chloride / ethyl acetate; methanol / 6.67 h / 0 °C / Reflux
2.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C / 2068.65 Torr
3.1: tert.-butylnitrite / acetonitrile / 0.25 h / 20 °C
3.2: 20 °C
4.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 4 h / -78 °C
5.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C
6.1: diethyl ether; tetrahydrofuran / -10 °C
With
tert.-butylnitrite; hydrogen; diisobutylaluminium hydride; acetyl chloride; pyridinium chlorochromate;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; ethyl acetate; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / palladium 10% on activated carbon / ethanol / 1 h / 20 °C / 2068.65 Torr
2.1: tert.-butylnitrite / acetonitrile / 0.25 h / 20 °C
2.2: 20 °C
3.1: diisobutylaluminium hydride / dichloromethane; tetrahydrofuran / 4 h / -78 °C
4.1: pyridinium chlorochromate / dichloromethane / 1 h / 20 °C
5.1: diethyl ether; tetrahydrofuran / -10 °C
With
tert.-butylnitrite; hydrogen; diisobutylaluminium hydride; pyridinium chlorochromate;
palladium 10% on activated carbon;
In
tetrahydrofuran; diethyl ether; ethanol; dichloromethane; acetonitrile;