methyl 5-amino-5-oxo-4-(1-oxo-4-(4-(2-pyrrolidin-1-ylethoxy)benzyloxy)isoindolin-2-yl)pentanoate

Base Information

Chemical Name:methyl 5-amino-5-oxo-4-(1-oxo-4-(4-(2-pyrrolidin-1-ylethoxy)benzyloxy)isoindolin-2-yl)pentanoate
CAS No.:1323407-27-7
Molecular Formula:C₂₇H₃₃N₃O₆
Molecular Weight:495.576
Hs Code.:

Synonyms:methyl 5-amino-5-oxo-4-(1-oxo-4-(4-(2-pyrrolidin-1-ylethoxy)benzyloxy)isoindolin-2-yl)pentanoate

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Chemical Property of methyl 5-amino-5-oxo-4-(1-oxo-4-(4-(2-pyrrolidin-1-ylethoxy)benzyloxy)isoindolin-2-yl)pentanoate

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Technology Process of methyl 5-amino-5-oxo-4-(1-oxo-4-(4-(2-pyrrolidin-1-ylethoxy)benzyloxy)isoindolin-2-yl)pentanoate

There total 8 articles about methyl 5-amino-5-oxo-4-(1-oxo-4-(4-(2-pyrrolidin-1-ylethoxy)benzyloxy)isoindolin-2-yl)pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 1323407-16-4
4-carbamoyl-4-(4-hydroxy-1-oxo-1,3-dihydro-isoindol-2-yl)-butyric acid methyl ester

: 262425-92-3
(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)methanol

: 1323407-27-7
methyl 5-amino-5-oxo-4-(1-oxo-4-(4-(2-pyrrolidin-1-ylethoxy)benzyloxy)isoindolin-2-yl)pentanoate

Guidance literature:: With di-isopropyl azodicarboxylate; In tetrahydrofuran; at 5 - 20 ℃;

Reference yield:

: 55289-05-9
methyl 3-hydroxy-2-methylbenzoate

: 1323407-27-7
methyl 5-amino-5-oxo-4-(1-oxo-4-(4-(2-pyrrolidin-1-ylethoxy)benzyloxy)isoindolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 5 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 1 - 20 °C

2: N-Bromosuccinimide / acetic acid methyl ester / 4 h / 40 °C / Irradiation

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 20 - 40 °C

4: water; potassium carbonate / N,N-dimethyl-formamide / 45 h / 20 °C

5: di-isopropyl azodicarboxylate / tetrahydrofuran / 5 - 20 °C

With 1H-imidazole; N-Bromosuccinimide; di-isopropyl azodicarboxylate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetic acid methyl ester; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1323407-17-5
2-bromomethyl-3-(tert-butyl-dimethyl-silanyloxy)-benzoic acid methyl ester

: 1323407-27-7
methyl 5-amino-5-oxo-4-(1-oxo-4-(4-(2-pyrrolidin-1-ylethoxy)benzyloxy)isoindolin-2-yl)pentanoate

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 20 - 40 °C

2: water; potassium carbonate / N,N-dimethyl-formamide / 45 h / 20 °C

3: di-isopropyl azodicarboxylate / tetrahydrofuran / 5 - 20 °C

With di-isopropyl azodicarboxylate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;