55289-05-9

Basic information

• Product Name: METHYL 3-HYDROXY-2-METHYLBENZOATE
• Synonyms: METHYL 3-HYDROXY-2-METHYLBENZOATE;Methyl 2-methyl-3-hydroxybenzoate;3-Hydroxy-2-methylbenzoic acid methyl ester;Benzoic acid, 3-hydroxy-2-methyl-, methyl ester
• CAS NO: 55289-05-9
• Molecular Formula: C₉H₁₀O₃
• Molecular Weight: 166.1739
• EINECS: 200-258-5
• Product Categories: Aromatic Esters
• Mol File: 55289-05-9.mol
• Article Data: 41

Chemical Properties

• Melting Point: 66-67 °C(Solv: hexane (110-54-3))
• Boiling Point: 282.2±20.0 °C(Predicted)
• Appearance: /
• Density: 1.169±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 9.50±0.10(Predicted)
• CAS DataBase Reference: METHYL 3-HYDROXY-2-METHYLBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 3-HYDROXY-2-METHYLBENZOATE(55289-05-9)
• EPA Substance Registry System: METHYL 3-HYDROXY-2-METHYLBENZOATE(55289-05-9)

Safety Data

• Hazardous Substances Data: 55289-05-9(Hazardous Substances Data)

Usage

General Description

Methyl 3-hydroxy-2-methylbenzoate is a compound with the chemical formula C9H10O3. It is a methyl ester derivative of 3-hydroxy-2-methylbenzoic acid and is commonly used as a flavoring agent in food and beverages. It is also used in the synthesis of various pharmaceuticals and as a fragrance ingredient in cosmetics and personal care products. Methyl 3-hydroxy-2-methylbenzoate has a sweet, fruity odor and is known for its pleasant aroma and taste. It is important to handle this chemical with caution, as it may cause irritation to the skin, eyes, and respiratory system if not properly handled.

Upstream product

• 59382-59-1 2-methyl-3-nitro-benzoic acid methyl ester 
• 52130-17-3 3-amino-2-methylbenzoic acid 
• 603-80-5 3-hydroxy 2-methylbenzoic acid 
• 144-55-8 sodium hydrogencarbonate 
• 75-36-5 acetyl chloride 
• 67-56-1 methanol 
• 83-41-0 2,3-dimethylnitrobenzene 
• 95-47-6 o-xylene 
• 55289-04-8 3-hydroxy-2-methylbenzonitrile 
• 3260-87-5 3-chloro-o-cresol 
• 1975-50-4 2-methyl-3-nitrobenzic acid 
• 18583-89-6 methyl 3-amino-2-methylbenzoate 
• 1120-73-6 2-methyl-2-cyclopenten-1-one 

Downstream Products

• 55289-15-1 methyl 6-bromo-3-hydroxy-2-methylbenzoate 
• 42981-93-1 3-methoxy-2-methylbenzoic acid methyl ester 
• 467252-04-6 methyl 3-isobutoxy-2-methylbenzoate 
• 55289-16-2 methyl 6-bromo-3-methoxy-2-methylbenzoate 
• 55289-17-3 6-bromo-3-methoxy-2-methylbenzoic acid 
• 55289-18-4 methyl 6-cyano-3-methoxy-2-methylbenzoate 
• 55289-21-9 4-methoxy-3-methyl-phthalic acid 
• 134154-59-9 methyl 2-methyl-3-(naphth-2-ylmethoxy)benzoate 
• 1149387-99-4 methyl 3-(allyloxy)-2-methylbenzoate 
• 24487-91-0 3-methoxy-2-methylbenzoyl chloride 
• 55289-06-0 3-methoxy-2-methylbenzoic acid 
• 330193-63-0 methyl 2-bromomethyl-3-methoxymethoxybenzoate 
• 1323402-50-1 3-{4-[4-(2-(morpholin-4-yl)ethyl)benzyloxy]-1-oxo-1,3-dihydroisoindol-2-yl}piperidine-2,6-dione 
• 1323407-38-0 4-carbamoyl-4-{4-[4-(2-(morpholin-4-yl)ethyl)benzyloxy]-1-oxo-1,3-dihydro-isoindol-2-yl}butyric acid methyl ester 

Relevant articles and documents

Co-production process of methyl 3-hydroxy-2-methyl benzoate and methyl 3-methoxy-2-methyl benzoate

The invention discloses a co-production process of 3-hydroxy-2-methyl benzoate and 3-methoxy-2-methyl benzoate, which comprises the following steps: (1) reduction hydrogenation reaction: by taking 2-methyl-3-nitrobenzoic acid or methyl 2-methyl-3-nitroben

Influence of Linker Attachment Points on the Stability and Neosubstrate Degradation of Cereblon Ligands

Proteolysis targeting chimeras (PROTACs) hijacking the cereblon (CRBN) E3 ubiquitin ligase have emerged as a novel paradigm in drug development. Herein we found that linker attachment points of CRBN ligands highly affect their aqueous stability and neosubstrate degradation features. This work provides a blueprint for the assembly of future heterodimeric CRBN-based degraders with tailored properties.

DEGRADERS OF WEE1 KINASE

Disclosed are bifunctional compounds (degraders) that target Wee1 tyrosine kinase for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat disease.