3-(1-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)benzyloxy)isoindolin-2-yl)piperidine-2,6-dione

Base Information

Chemical Name:3-(1-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)benzyloxy)isoindolin-2-yl)piperidine-2,6-dione
CAS No.:1323402-44-3
Molecular Formula:C₂₆H₂₉N₃O₅
Molecular Weight:463.533
Hs Code.:

Synonyms:3-(1-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)benzyloxy)isoindolin-2-yl)piperidine-2,6-dione

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Chemical Property of 3-(1-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)benzyloxy)isoindolin-2-yl)piperidine-2,6-dione

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Technology Process of 3-(1-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)benzyloxy)isoindolin-2-yl)piperidine-2,6-dione

There total 9 articles about 3-(1-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)benzyloxy)isoindolin-2-yl)piperidine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 1323407-27-7
methyl 5-amino-5-oxo-4-(1-oxo-4-(4-(2-pyrrolidin-1-ylethoxy)benzyloxy)isoindolin-2-yl)pentanoate

: 1323402-44-3
3-(1-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)benzyloxy)isoindolin-2-yl)piperidine-2,6-dione

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 5 - 20 ℃; for 2.1666h;

Reference yield:

: 55289-05-9
methyl 3-hydroxy-2-methylbenzoate

: 1323402-44-3
3-(1-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)benzyloxy)isoindolin-2-yl)piperidine-2,6-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 1 - 20 °C

2: N-Bromosuccinimide / acetic acid methyl ester / 4 h / 40 °C / Irradiation

3: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 20 - 40 °C

4: water; potassium carbonate / N,N-dimethyl-formamide / 45 h / 20 °C

5: di-isopropyl azodicarboxylate / tetrahydrofuran / 5 - 20 °C

6: potassium tert-butylate / tetrahydrofuran / 2.17 h / 5 - 20 °C

With 1H-imidazole; N-Bromosuccinimide; di-isopropyl azodicarboxylate; potassium tert-butylate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetic acid methyl ester; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1323407-17-5
2-bromomethyl-3-(tert-butyl-dimethyl-silanyloxy)-benzoic acid methyl ester

: 1323402-44-3
3-(1-oxo-4-(4-(2-(pyrrolidin-1-yl)ethoxy)benzyloxy)isoindolin-2-yl)piperidine-2,6-dione

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 24 h / 20 - 40 °C

2: water; potassium carbonate / N,N-dimethyl-formamide / 45 h / 20 °C

3: di-isopropyl azodicarboxylate / tetrahydrofuran / 5 - 20 °C

4: potassium tert-butylate / tetrahydrofuran / 2.17 h / 5 - 20 °C

With di-isopropyl azodicarboxylate; potassium tert-butylate; water; potassium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;