2-(2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinyl)-4-(4-fluorophenyl)thiazole

Base Information

Chemical Name:2-(2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinyl)-4-(4-fluorophenyl)thiazole
CAS No.:1334025-50-1
Molecular Formula:C₂₅H₁₇Cl₂FN₄S
Molecular Weight:495.407
Hs Code.:

Synonyms:2-(2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinyl)-4-(4-fluorophenyl)thiazole

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Chemical Property of 2-(2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinyl)-4-(4-fluorophenyl)thiazole

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Technology Process of 2-(2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinyl)-4-(4-fluorophenyl)thiazole

There total 3 articles about 2-(2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinyl)-4-(4-fluorophenyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 302945-51-3
2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinecarbothioamide

: 403-29-2
2-bromo-4'-fluoroacetophenone

: 1334025-50-1
2-(2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinyl)-4-(4-fluorophenyl)thiazole

Guidance literature:: In tetrahydrofuran; at 30 ℃; for 1.5h;

Reference yield:

: 90815-03-5
1-[(2,4-dichlorophenyl)methyl]-1H-indole-3-carboxaldehyde

: 1334025-50-1
2-(2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinyl)-4-(4-fluorophenyl)thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / tetrahydrofuran / Reflux

2: triethylamine / tetrahydrofuran / 0.5 h / 20 °C

With acetic acid; triethylamine; In tetrahydrofuran; 2: Hantzsch reaction;
DOI:10.1016/j.bmcl.2011.06.076

Reference yield:

: 403-42-9
1-(4-fluorophenyl)ethanone

: 1334025-50-1
2-(2-((1-(2,4-dichlorobenzyl)-1H-indol-3-yl)methylene)hydrazinyl)-4-(4-fluorophenyl)thiazole

Guidance literature:: Multi-step reaction with 2 steps

1: aluminum (III) chloride; bromine / diethyl ether / 0 - 20 °C

2: triethylamine / tetrahydrofuran / 0.5 h / 20 °C

With aluminum (III) chloride; bromine; triethylamine; In tetrahydrofuran; diethyl ether; 2: Hantzsch reaction;
DOI:10.1016/j.bmcl.2011.06.076