ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(tert-butyldimethylsilyloxy)-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate

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Chemical Name:ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(tert-butyldimethylsilyloxy)-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate
CAS No.:1224848-84-3
Molecular Formula:C₄₃H₅₂N₄O₅Si
Molecular Weight:732.995
Hs Code.:

Synonyms:ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(tert-butyldimethylsilyloxy)-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate

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Chemical Property of ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(tert-butyldimethylsilyloxy)-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate

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Technology Process of ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(tert-butyldimethylsilyloxy)-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate

There total 9 articles about ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(tert-butyldimethylsilyloxy)-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1224848-83-2
ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)-3-hydroxypropanoate

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1224848-84-3
ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(tert-butyldimethylsilyloxy)-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate

Guidance literature:: With 1H-imidazole; In chloroform; at 20 ℃; for 20h;

Reference yield:

: 553-03-7
3,4-dihydro-2(1H)-quinolone

: 1224848-84-3
ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(tert-butyldimethylsilyloxy)-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / Cooling with ice

1.2: 1 h / -30 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

3.1: manganese(IV) oxide / chloroform / 15 h / 20 °C

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

4.2: 1 h / -78 °C

5.1: 1H-imidazole / chloroform / 20 h / 20 °C

With 1H-imidazole; manganese(IV) oxide; lithium aluminium tetrahydride; potassium tert-butylate; lithium hexamethyldisilazane; In tetrahydrofuran; chloroform;

Reference yield:

: 1224847-65-7
ethyl 4,5-dihydroimidazo[1,5-a]quinoline-3-carboxylate

: 1224848-84-3
ethyl 2-{2-[bis(4-methoxybenzyl)amino]pyridin-4-yl}-3-(tert-butyldimethylsilyloxy)-3-(4,5-dihydroimidazo[1,5-a]quinolin-3-yl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / Cooling with ice

2.1: manganese(IV) oxide / chloroform / 15 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

3.2: 1 h / -78 °C

4.1: 1H-imidazole / chloroform / 20 h / 20 °C

With 1H-imidazole; manganese(IV) oxide; lithium aluminium tetrahydride; lithium hexamethyldisilazane; In tetrahydrofuran; chloroform;