1-(4-METHOXY-PHENYL)-3-PHENYL-PROPYNONE

Base Information

• Chemical Name: 1-(4-METHOXY-PHENYL)-3-PHENYL-PROPYNONE
• CAS No.: 16616-43-6
• Molecular Formula: C16H12 O2
• Molecular Weight: 236.27
• Hs Code.: 2914509090
• Mol file: 16616-43-6.mol

Synonyms:Propiolophenone,4'-methoxy-3-phenyl- (8CI); (p-Methoxybenzoyl)phenylacetylene;1-(4-Methoxyphenyl)-3-phenyl-2-propyn-1-one;1-(4-Methoxyphenyl)-3-phenyl-2-propynone; 4-Methoxybenzoyl(phenyl)ethyne;4-Methoxyphenyl phenethynyl ketone; 4-Methoxyphenyl phenylethynyl ketone;4'-Methoxy-3-phenylpropiolophenone; p-Anisoylphenylacetylene

Chemical Property of 1-(4-METHOXY-PHENYL)-3-PHENYL-PROPYNONE

Chemical Property:

• Melting Point: 90-92 °C
• Boiling Point: 392.1±44.0 °C(Predicted)
• PSA: 26.30000
• Density: 1.16±0.1 g/cm3(Predicted)
• LogP: 2.92960

Purity/Quality:

99% ^*data from raw suppliers

1-(4-METHOXY-PHENYL)-3-PHENYL-PROPYNONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-METHOXY-PHENYL)-3-PHENYL-PROPYNONE

There total 70 articles about 1-(4-METHOXY-PHENYL)-3-PHENYL-PROPYNONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxy-benzoyl chloride (100-07-2) + phenylacetylene (536-74-3) → 1-(4-methoxy-phenyl)-3-phenyl-propynone (16616-43-6)

Guidance literature:

4-methoxy-benzoyl chloride; With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

With copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 0.166667h; Inert atmosphere;

phenylacetylene; In tetrahydrofuran; at 20 ℃; for 6.25h; Inert atmosphere;

DOI:10.1016/j.tet.2015.04.070

Reference yield: 98.0%

1-(4-methoxyphenyl)-3-phenylprop-2-yn-1-ol (116460-49-2,102990-13-6) → 1-(4-methoxy-phenyl)-3-phenyl-propynone (16616-43-6)

Guidance literature:

With tert.-butylhydroperoxide; [2,2]bipyridinyl; In dichloromethane; water; at 20 ℃; for 1h;

DOI:10.1055/s-0030-1261227

Reference yield: 97.0%

carbon monoxide (201230-82-2) + para-iodoanisole (696-62-8) + phenylacetylene (536-74-3) → 1-(4-methoxy-phenyl)-3-phenyl-propynone (16616-43-6)

Guidance literature:

With triethylamine; palladium on activated charcoal; In toluene; at 130 ℃; for 4h; under 15001.5 Torr;

DOI:10.1016/j.jcat.2007.10.021

upstream raw materials:

(phenylethynyl)sodium

4-methoxy-benzoyl chloride

phenylpropiolyl chloride

methoxybenzene

Downstream raw materials:

5-(4-methoxyphenyl)-3-phenylisoxazole

1-(4-methoxy-phenyl)-3-morpholin-4-yl-3-phenyl-propenone

1-(p-Methoxyphenyl)-3-phenyl-3-(pyrid-2-ylamino)-2-propen-1-one

(E,Z)-3,3'-Thiodi(1-p-methoxyphenyl-3-phenylprop-2-en-1-one)

Refernces

Temperature-gradient-directed NMR monitoring of a [3 + 3]-cyclocondensation reaction between alkynone and ethyl 2-amino-1 H-indole-3-carboxylate toward the synthesis of pyrimido[1,2-a]indole catalyzed by Cs₂CO₃

10.1080/00397911.2012.687423

The research focuses on the synthesis of pyrimido[1,2-a]indole through a [3+3]-cyclocondensation reaction between alkynone and ethyl 2-amino-1H-indole-3-carboxylate, catalyzed by Cs2CO3. The main content involves the use of temperature-gradient-directed NMR monitoring to observe the real-time chemical reaction, which is a noninvasive technique allowing for the optimization of reaction conditions and quantitative analysis of the product. The reactants used in the experiments include ethyl 2-amino-1H-indole-3-carboxylates (1), 1-(4-methoxyphenyl)-3-phenylprop-2-yn-1-one (2), and the catalyst Cs2CO3. The analyses conducted encompassed NMR spectroscopy, high-resolution magic angle spinning (HR-MAS) NMR, and high-performance liquid chromatography (HPLC) to characterize the products and monitor the reaction progress.