2-benzyl 2'-[2-(trimethylsilyl)ethyl] 4-(isobutylamino)carbonyl-4'-methoxybiphenyl-2,2'-dicarboxylate

Base Information

Chemical Name:2-benzyl 2'-[2-(trimethylsilyl)ethyl] 4-(isobutylamino)carbonyl-4'-methoxybiphenyl-2,2'-dicarboxylate
CAS No.:916904-06-8
Molecular Formula:C₃₂H₃₉NO₆Si
Molecular Weight:561.75
Hs Code.:

Synonyms:2-benzyl 2'-[2-(trimethylsilyl)ethyl] 4-(isobutylamino)carbonyl-4'-methoxybiphenyl-2,2'-dicarboxylate

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Chemical Property of 2-benzyl 2'-[2-(trimethylsilyl)ethyl] 4-(isobutylamino)carbonyl-4'-methoxybiphenyl-2,2'-dicarboxylate

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Technology Process of 2-benzyl 2'-[2-(trimethylsilyl)ethyl] 4-(isobutylamino)carbonyl-4'-methoxybiphenyl-2,2'-dicarboxylate

There total 7 articles about 2-benzyl 2'-[2-(trimethylsilyl)ethyl] 4-(isobutylamino)carbonyl-4'-methoxybiphenyl-2,2'-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 916904-05-7
2-(trimethylsilyl)ethyl 2-bromo-5-methoxybenzoate

: 420797-67-7
benzyl 5-(isobutylamino)carbonyl-2-{[(trifluoromethyl)sulfonyl]oxy}benzoate

: 916904-06-8
2-benzyl 2'-[2-(trimethylsilyl)ethyl] 4-(isobutylamino)carbonyl-4'-methoxybiphenyl-2,2'-dicarboxylate

Guidance literature:: With potassium phosphate; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 120 ℃; for 12h;
DOI:10.1016/j.bmc.2006.08.010

Reference yield:

: 239462-58-9
benzyl 2-trifluoromethylsulfonyloxy-5-formylbenzoate

: 916904-06-8
2-benzyl 2'-[2-(trimethylsilyl)ethyl] 4-(isobutylamino)carbonyl-4'-methoxybiphenyl-2,2'-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: NaH₂PO₄*H₂O; 2-methyl-2-butene; sodium chlorite / 2-methyl-propan-2-ol; H₂O; acetonitrile / 1 h / 20 °C

2: oxalyl chloride / CH₂Cl₂; dimethylformamide / 2 h / 20 °C

3: 2.89 g / triethylamine / CH₂Cl₂ / 1 h / 0 °C

4: 34 percent / bis(pinacolato)diboron; K₃PO₄ / PdCl₂(dppf)*CH₂Cl₂ / dimethylformamide / 12 h / 120 °C

With sodium chlorite; potassium phosphate; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; triethylamine; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; tert-butyl alcohol;
DOI:10.1016/j.bmc.2006.08.010

Reference yield:

: 239462-49-8
3-benzyloxycarbonyl-4-trifluoromethylsulfonyloxy-benzoic acid

: 916904-06-8
2-benzyl 2'-[2-(trimethylsilyl)ethyl] 4-(isobutylamino)carbonyl-4'-methoxybiphenyl-2,2'-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: oxalyl chloride / CH₂Cl₂; dimethylformamide / 2 h / 20 °C

2: 2.89 g / triethylamine / CH₂Cl₂ / 1 h / 0 °C

3: 34 percent / bis(pinacolato)diboron; K₃PO₄ / PdCl₂(dppf)*CH₂Cl₂ / dimethylformamide / 12 h / 120 °C

With potassium phosphate; oxalyl dichloride; triethylamine; bis(pinacol)diborane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.010