2-(2,4-difluorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol

Base Information

Chemical Name:2-(2,4-difluorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol
CAS No.:146796-52-3
Molecular Formula:C₁₇H₁₈F₂N₄O₂S
Molecular Weight:380.418
Hs Code.:

Synonyms:2-(2,4-difluorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol

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Chemical Property of 2-(2,4-difluorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol

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Technology Process of 2-(2,4-difluorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol

There total 4 articles about 2-(2,4-difluorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 300-87-8
3,5-dimethyl-1,2-oxazole

: 146796-52-3
2-(2,4-difluorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen chloride, 35percent aq. hydrochloric acid / 65 - 70 °C

2: 42 percent / thionyl chloride / CH₂Cl₂ / 1.5 h / Ambient temperature

3: 96 percent / 2 M aq. sodium trithiocarbonate / methanol / 1 h / 0 °C

4: 1.) sodium hydride / 1.) DMF, RT, 30 min., 2.) DMF, RT, 48 h

With hydrogenchloride; thionyl chloride; sodium trithiocarbonate; sodium hydride; In methanol; dichloromethane;
DOI:10.1002/jhet.5570290631

Reference yield:

: 19788-37-5
4-chloromethyl-3,5-dimethylisoxazole

: 146796-52-3
2-(2,4-difluorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / 2 M aq. sodium trithiocarbonate / methanol / 1 h / 0 °C

2: 1.) sodium hydride / 1.) DMF, RT, 30 min., 2.) DMF, RT, 48 h

With sodium trithiocarbonate; sodium hydride; In methanol;
DOI:10.1002/jhet.5570290631

Reference yield:

: 19788-36-4
4-hydroxymethyl-3,5-dimethylisoxazole

: 146796-52-3
2-(2,4-difluorophenyl)-3-((3,5-dimethylisoxazol-4-yl)methylyhio)-1-(1,2,4-triazol-1-yl)-2-propanol

Guidance literature:: Multi-step reaction with 3 steps

1: 42 percent / thionyl chloride / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 96 percent / 2 M aq. sodium trithiocarbonate / methanol / 1 h / 0 °C

3: 1.) sodium hydride / 1.) DMF, RT, 30 min., 2.) DMF, RT, 48 h

With thionyl chloride; sodium trithiocarbonate; sodium hydride; In methanol; dichloromethane;
DOI:10.1002/jhet.5570290631