(1-(3-chlorophenyl)-4-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine

Base Information

Chemical Name:(1-(3-chlorophenyl)-4-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine
CAS No.:1254716-64-7
Molecular Formula:C₁₂H₁₁ClF₃N₃
Molecular Weight:289.688
Hs Code.:

Synonyms:(1-(3-chlorophenyl)-4-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine

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Chemical Property of (1-(3-chlorophenyl)-4-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine

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Technology Process of (1-(3-chlorophenyl)-4-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine

There total 6 articles about (1-(3-chlorophenyl)-4-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1254716-74-9
1-(3-chlorophenyl)-4-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonitrile

: 1254716-64-7
(1-(3-chlorophenyl)-4-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine

Guidance literature:: 1-(3-chlorophenyl)-4-methyl-3-(trifluoromethyl)-1H-pyrazole-5-carbonitrile; With borane-THF; In tetrahydrofuran; at 0 - 50 ℃;

With hydrogenchloride; In tetrahydrofuran; at 0 - 20 ℃;

With sodium hydroxide; In tetrahydrofuran; pH=12;

Reference yield:

: 108-42-9
3-chloro-aniline

: 1254716-64-7
(1-(3-chlorophenyl)-4-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; sodium nitrite; tin(II) chloride hydrate / water / 2 h / -5 - 0 °C

1.2: pH 9

2.1: hydrogenchloride / ethanol / 2 h / Reflux

2.2: pH 12

3.1: copper(I) bromide; n-Butyl nitrite / acetonitrile / 0.25 h / 150 °C

4.1: sodium iodide / 1-methyl-pyrrolidin-2-one / 8 h / 180 °C

5.1: borane-THF / tetrahydrofuran / 12 h / 5 - 50 °C

5.2: 2 h / 5 - 20 °C

5.3: pH ~ 12

With hydrogenchloride; borane-THF; tin(II) chloride hydrate; n-Butyl nitrite; copper(I) bromide; sodium nitrite; sodium iodide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; water; acetonitrile;

Reference yield:

: 14763-20-3
3-chlorophenyl hydrazine

: 1254716-64-7
(1-(3-chlorophenyl)-4-methyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)methanamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / ethanol / 2 h / Reflux

1.2: pH 12

2.1: copper(I) bromide; n-Butyl nitrite / acetonitrile / 0.25 h / 150 °C

3.1: sodium iodide / 1-methyl-pyrrolidin-2-one / 8 h / 180 °C

4.1: borane-THF / tetrahydrofuran / 12 h / 5 - 50 °C

4.2: 2 h / 5 - 20 °C

4.3: pH ~ 12

With hydrogenchloride; borane-THF; n-Butyl nitrite; copper(I) bromide; sodium iodide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; acetonitrile;