N-(4-amino-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-2,5-dichloro-benzenesulfonamide

Base Information

• Chemical Name: N-(4-amino-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-2,5-dichloro-benzenesulfonamide
• CAS No.: 473465-38-2
• Molecular Formula: C₉H₉Cl₂N₅O₂S₂
• Molecular Weight: 354.241

Synonyms:N-(4-amino-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-2,5-dichloro-benzenesulfonamide

Chemical Property of N-(4-amino-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-2,5-dichloro-benzenesulfonamide

Chemical Property:

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Technology Process of N-(4-amino-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-2,5-dichloro-benzenesulfonamide

There total 2 articles about N-(4-amino-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-2,5-dichloro-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

Thiocarbohydrazide (2231-57-4) + (2,5-dichloro-benzenesulfonylamino)-acetic acid (109518-76-5) → N-(4-amino-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-2,5-dichloro-benzenesulfonamide (473465-38-2)

Guidance literature:

at 180 ℃; for 0.25h;

DOI:10.1002/hc.10037

Reference yield:

2,5-dichlorobenzenesulphonyl chloride (5402-73-3) → N-(4-amino-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-2,5-dichloro-benzenesulfonamide (473465-38-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 10 percent sodium hydroxide / diethyl ether / 3 h / 20 °C

2: 74 percent / 0.25 h / 180 °C

With sodium hydroxide; In diethyl ether;

DOI:10.1002/hc.10037

Reference yield: 88.0%

4-chlorobenzaldehyde (104-88-1) + N-(4-amino-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-2,5-dichloro-benzenesulfonamide (473465-38-2) → 2,5-Dichloro-N-(4-{[1-(4-chloro-phenyl)-meth-(E)-ylidene]-amino}-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-benzenesulfonamide

Guidance literature:

In acetic acid; for 5h; Heating;

DOI:10.1002/hc.10037

upstream raw materials:

Thiocarbohydrazide

(2,5-dichloro-benzenesulfonylamino)-acetic acid

2,5-dichlorobenzenesulphonyl chloride

Downstream raw materials:

2,5-Dichloro-N-(4-{[1-phenyl-meth-(E)-ylidene]-amino}-5-thioxo-4,5-dihydro-1H-[1,2,4]triazol-3-ylmethyl)-benzenesulfonamide

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