(+/-)-2-(methylsulfinyl)thiophene

Base Information

• Chemical Name: (+/-)-2-(methylsulfinyl)thiophene
• CAS No.: 74166-42-0
• Molecular Formula: C₅H₆OS₂
• Molecular Weight: 146.234
• Mol file: 74166-42-0.mol

Synonyms:(+/-)-2-(methylsulfinyl)thiophene

Chemical Property of (+/-)-2-(methylsulfinyl)thiophene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (+/-)-2-(methylsulfinyl)thiophene

There total 1 articles about (+/-)-2-(methylsulfinyl)thiophene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 3.0%

2-(methylsulfanyl)thiophene (5780-36-9) → Methyl-<2>thienylsulfon (38695-60-2) + (+/-)-2-(methylsulfinyl)thiophene (74166-42-0)

Guidance literature:

With dihydrogen peroxide; In acetone; for 288h; Ambient temperature;

DOI:10.1007/BF00938722

Reference yield: 78.0%

1-phenylcyclopropan-1-ol (29526-96-3) + (+/-)-2-(methylsulfinyl)thiophene (74166-42-0) → C14H14OS2

Guidance literature:

With 2,2,3,3,3-pentafluoropropanoic anhydride; sodium 2,2,2-trifluoroacetate; In dichloromethane; at 20 ℃; for 8h; regioselective reaction; Inert atmosphere; Molecular sieve;

DOI:10.1021/acs.orglett.9b01908

Reference yield: 77.0%

4-methylphenyl methylsulfide (623-13-2) + (+/-)-2-(methylsulfinyl)thiophene (74166-42-0) → 5-methylsulfanyl-2-thienyl 4-tolyl sulfide

Guidance literature:

4-methylphenyl methylsulfide; (+/-)-2-(methylsulfinyl)thiophene; With trifluoromethylsulfonic anhydride; trifluoroacetic anhydride; In dichloromethane; at 25 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

With ethanolamine; In dichloromethane; at 25 ℃; for 3h; regioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02147

upstream raw materials:

2-(methylsulfanyl)thiophene

Downstream raw materials:

2-(4-methoxyphenyl)thiophene

Methyl-<2>thienylsulfon