21-Acetyloxy-9-fluoro-11-(trifluoroace-tyloxy)-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione

Base Information

Chemical Name:21-Acetyloxy-9-fluoro-11-(trifluoroace-tyloxy)-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione
CAS No.:16394-70-0
Molecular Formula:C₂₆H₃₀F₄O₇
Molecular Weight:530.514
Hs Code.:
Mol file:16394-70-0.mol

Synonyms:Pregna-1,4-diene-3,20-dione,21-(acetyloxy)-9-fluoro-17-hydroxy-16-methyl-11-[(trifluoroacetyl)oxy]-, (11b,16b)- (9CI); Pregna-1,4-diene-3,20-dione, 9-fluoro-11b,17,21-trihydroxy-16b-methyl-, 21-acetate11-(trifluoroacetate) (8CI)

Suppliers and Price of 21-Acetyloxy-9-fluoro-11-(trifluoroace-tyloxy)-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 21-Acetyloxy-9-fluoro-11-(trifluoroace-tyloxy)-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione

Chemical Property:

PSA：106.97000
LogP:3.57970

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 21-Acetyloxy-9-fluoro-11-(trifluoroace-tyloxy)-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione

There total 2 articles about 21-Acetyloxy-9-fluoro-11-(trifluoroace-tyloxy)-17-hydroxy-16-methylpregna-1,4-diene-3,20-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.7%

: 16319-51-0
(11β,16β)-9-fluoro-17,21-dihydroxy-16-methyl-3,20-dioxo-11-trifluoroacetoxy-pregna-1,4-diene

: 108-24-7
acetic anhydride

: 16394-70-0
(11β,16β)-9-fluoro-17-hydroxy-16-methyl-3,20-dioxo-11-trifluoroacetoxy-21-acetoxy-pregna-1,4-diene

Guidance literature:: With dmap; In tetrahydrofuran; at 18 - 25 ℃; for 15h;

Reference yield:

: 378-44-9
betamethasone

: 16394-70-0
(11β,16β)-9-fluoro-17-hydroxy-16-methyl-3,20-dioxo-11-trifluoroacetoxy-21-acetoxy-pregna-1,4-diene

Guidance literature:: Multi-step reaction with 2 steps

1.1: dmap / tetrahydrofuran / 15.33 h / 10 - 25 °C

1.2: 15 h

2.1: dmap / tetrahydrofuran / 15 h / 18 - 25 °C

With dmap; In tetrahydrofuran;