4-[5-Bromo-2-(piperidin-4-ylamino)pyrimidin-4-yloxy]-3,5-dimethyl-benzonitrile

Base Information

• Chemical Name: 4-[5-Bromo-2-(piperidin-4-ylamino)pyrimidin-4-yloxy]-3,5-dimethyl-benzonitrile
• CAS No.: 1033954-44-7
• Molecular Formula: C₁₈H₂₀BrN₅O
• Molecular Weight: 402.294

Synonyms:4-[5-Bromo-2-(piperidin-4-ylamino)pyrimidin-4-yloxy]-3,5-dimethyl-benzonitrile

Chemical Property of 4-[5-Bromo-2-(piperidin-4-ylamino)pyrimidin-4-yloxy]-3,5-dimethyl-benzonitrile

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Technology Process of 4-[5-Bromo-2-(piperidin-4-ylamino)pyrimidin-4-yloxy]-3,5-dimethyl-benzonitrile

There total 1 articles about 4-[5-Bromo-2-(piperidin-4-ylamino)pyrimidin-4-yloxy]-3,5-dimethyl-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C23H28BrN5O3 → 4-[5-Bromo-2-(piperidin-4-ylamino)pyrimidin-4-yloxy]-3,5-dimethyl-benzonitrile (1033954-44-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmcl.2010.05.040

Reference yield:

4-[5-Bromo-2-(piperidin-4-ylamino)pyrimidin-4-yloxy]-3,5-dimethyl-benzonitrile (1033954-44-7) + 3-acetylaminobenzaldehyde (59755-25-8) → N-(3-{4-[5-Bromo-4-(4-cyano-2,6-dimethylphenoxy)-pyrimidin-2-ylamino]-piperidin-1-ylmethyl}-phenyl)-acetamide (1033951-04-0)

Guidance literature:

With PL-cyanoborohydride resin; acetic acid; In methanol; dichloromethane; acetonitrile; at 20 ℃; for 24h;

Reference yield:

4-[5-Bromo-2-(piperidin-4-ylamino)pyrimidin-4-yloxy]-3,5-dimethyl-benzonitrile (1033954-44-7) + 4-(methylsulfonyl)benzyl bromide (53606-06-7) → 4-{5-Bromo-2-[1-(4-methanesulfonylbenzyl)-piperidin-4-ylamino]-pyrimidin-4-yloxy}-3,5-dimethyl-benzonitrile (1033951-07-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 24h;

Downstream raw materials:

N-(3-{4-[5-Bromo-4-(4-cyano-2,6-dimethylphenoxy)-pyrimidin-2-ylamino]-piperidin-1-ylmethyl}-phenyl)-acetamide

4-{5-Bromo-2-[1-(4-methanesulfonylbenzyl)-piperidin-4-ylamino]-pyrimidin-4-yloxy}-3,5-dimethyl-benzonitrile

4-{4-[5-Bromo-4-(4-cyano-2,6-dimethyl-phenoxy)-pyrimidin-2-ylamino]-piperidin-1-ylmethyl}-3-chloro-benzoic acid

4-{5-Bromo-2-[1-(2-chloro-4-methanesulfonyl-benzyl)-piperidin-4-ylamino]-pyrimidin-4-yloxy}-3,5-dimethyl-benzonitrile

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