2-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-cyclohexylacetamide

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Chemical Name:2-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-cyclohexylacetamide
CAS No.:1550169-15-7
Molecular Formula:C₂₄H₂₅F₃N₈O
Molecular Weight:498.511
Hs Code.:

Synonyms:2-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-cyclohexylacetamide

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Chemical Property of 2-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-cyclohexylacetamide

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Technology Process of 2-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-cyclohexylacetamide

There total 4 articles about 2-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-cyclohexylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 114703-80-9
2-azido-N-cyclohexylacetamide

: 1550170-74-5
6-phenyl-1-(prop-2-ynyl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine

: 1550169-15-7
2-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-cyclohexylacetamide

Guidance literature:: With copper(l) iodide; In tetrahydrofuran; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.12.107

Reference yield:

: 201224-86-4
6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-3-amine

: 1550169-15-7
2-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-cyclohexylacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; sodium iodide / acetone / 24 h / 20 - 60 °C

2: copper(l) iodide / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With copper(l) iodide; potassium carbonate; sodium iodide; In tetrahydrofuran; acetone;
DOI:10.1016/j.bmcl.2013.12.107

Reference yield:

: 108-91-8,157973-60-9
cyclohexylamine

: 1550169-15-7
2-(4-((3-amino-6-phenyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)methyl)-1H-1,2,3-triazol-1-yl)-N-cyclohexylacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide

2: sodium azide / N,N-dimethyl-formamide

3: copper(l) iodide / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

With copper(l) iodide; sodium azide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.12.107