2-tert-butoxycarbonylamino-3-phenyl-propionic acid benzotriazol-1-yl ester

Base Information

• Chemical Name: 2-tert-butoxycarbonylamino-3-phenyl-propionic acid benzotriazol-1-yl ester
• CAS No.: 99532-43-1
• Molecular Formula: C₂₀H₂₂N₄O₄
• Molecular Weight: 382.419
• Mol file: 99532-43-1.mol

Synonyms:2-tert-butoxycarbonylamino-3-phenyl-propionic acid benzotriazol-1-yl ester

Chemical Property of 2-tert-butoxycarbonylamino-3-phenyl-propionic acid benzotriazol-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 2-tert-butoxycarbonylamino-3-phenyl-propionic acid benzotriazol-1-yl ester

There total 5 articles about 2-tert-butoxycarbonylamino-3-phenyl-propionic acid benzotriazol-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-tert-butoxycarbonyl-L-phenylalanine (13734-34-4) + benzotriazol-1-ol (2592-95-2) → BOC-Phe-POBT (99532-43-1,80633-33-6)

Guidance literature:

With dicyclohexyl-carbodiimide; In chloroform; for 6h; Ambient temperature;

DOI:10.1039/c39900001045

Reference yield:

Boc-D-Phe-OH (18942-49-9) + benzotriazol-1-ol (2592-95-2) → 2-tert-butoxycarbonylamino-3-phenyl-propionic acid benzotriazol-1-yl ester (99532-43-1)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 ℃; for 0.166667h;

DOI:10.1021/jm020525x

Reference yield:

L-phenylalanine (63-91-2,25191-15-5,658-69-5,67675-33-6) → BOC-Phe-POBT (99532-43-1,80633-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 2-methyl-propan-2-ol; H₂O / pH 9.5-10.0

2: DCC / CH₂Cl₂; dimethylformamide / 2 h / 0 °C

With dicyclohexyl-carbodiimide; In dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;

upstream raw materials:

N-tert-butoxycarbonyl-L-phenylalanine

benzotriazol-1-ol

L-phenylalanine

di-tert-butyl dicarbonate

Downstream raw materials:

Boc-Phe-Asn-Glu(Bzl)-Asn-Met-Ala-Tyr(Bzl)-OMe

(S)-2-[(tert-butoxycarbonyl)amino]-3-phenylpropionamide

N-tert-butyloxycarbonyl-L-tyrosyl-glycyl-glycyl-L-phenylalanyl-L-leucine

(S)-6-(2-(tert-butoxycarbonylamino)-3-phenyl-propanamido)hexanoic acid