2-amino-N-methylbenzenesulfonamide

Base Information

• Chemical Name: 2-amino-N-methylbenzenesulfonamide
• CAS No.: 16288-77-0
• Molecular Formula: C7H10N2O2S
• Molecular Weight: 186.235
• Hs Code.: 2935009090
• European Community (EC) Number: 859-270-0
• DSSTox Substance ID: DTXSID70360623
• Wikidata: Q72439121
• Mol file: 16288-77-0.mol

Synonyms:2-amino-N-methylbenzenesulfonamide;16288-77-0;N-Methyl 2-aminobenzenesulfonamide;2-Amino-N-methyl-benzenesulfonamide;Benzenesulfonamide, 2-amino-N-methyl-;2-amino-N-methylbenzene-1-sulfonamide;Benzenesulfonamide,2-amino-N-methyl-;o-N-Methylsulfamylanilin;SCHEMBL375689;DTXSID70360623;CS-M2487;2-amino-N -methyl-benzenesulfonamide;MFCD04035388;STL411809;AKOS000148266;GS-4448;SY168114;AM20061135;FT-0645890;EN300-30706;A882770;Z278052022

Chemical Property of 2-amino-N-methylbenzenesulfonamide

Chemical Property:

• Vapor Pressure: 3.73E-05mmHg at 25°C
• Melting Point: 59-60℃
• Refractive Index: 1.581
• Boiling Point: 352.9 °C at 760 mmHg
• PKA: 11?+-.0.10(Predicted)
• Flash Point: 167.2 °C
• PSA: 80.57000
• Density: 1.308 g/cm³
• LogP: 2.22980
• Storage Temp.: 2-8°C(protect from light)
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 186.04629874
• Heavy Atom Count: 12
• Complexity: 232

Purity/Quality:

97% ^*data from raw suppliers

2-Amino-N-methylbenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CNS(=O)(=O)C1=CC=CC=C1N

Technology Process of 2-amino-N-methylbenzenesulfonamide

There total 8 articles about 2-amino-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-methyl-2-nitrobenzenesulfonamide (23530-40-7) → 2-amino-N-methylbenzenesulfonamide (16288-77-0)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃; for 3h;

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → 2-amino-N-methylbenzenesulfonamide (16288-77-0)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane; methanol / 0.67 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 20 °C

With hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; dichloromethane;

Reference yield:

2-acetylamino-benzenesulfonic acid methylamide (7781-47-7) → 2-amino-N-methylbenzenesulfonamide (16288-77-0)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

N-methyl-2-nitrobenzenesulfonamide

2-acetylamino-benzenesulfonic acid methylamide

(2-amino-benzenesulfonyl)-methyl-carbamic acid ethyl ester

ethyl ((2-nitrophenyl)sulfonyl)carbamate

Downstream raw materials:

2-methyl-3-phenyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-dioxide

N-(3-((5-chloro-4-((2-(N-methylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide

2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

2-((5-chloro-2-((3-nitrophenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide