2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

Base Information

• Chemical Name: 2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide
• CAS No.: 1346447-83-3
• Molecular Formula: C₁₇H₁₇ClN₆O₂S
• Molecular Weight: 404.88
• Mol file: 1346447-83-3.mol

Synonyms:2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

Chemical Property of 2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

There total 5 articles about 2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-((5-chloro-2-((3-nitrophenyl)amino)pyrimidin-4-yl)amino)-N-methylbenzenesulfonamide (1346447-82-2) → 2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide (1346447-83-3)

Guidance literature:

With hydrogen; platinum(IV) oxide; In ethyl acetate; for 2h;

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → 2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide (1346447-83-3)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / dichloromethane; methanol / 0.67 h / 0 - 20 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 6 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

4: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 80 °C

5: hydrogen / platinum(IV) oxide / ethyl acetate / 2 h

With hydrogen; potassium carbonate; toluene-4-sulfonic acid; triethylamine; platinum(IV) oxide; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

2-amino-N-methylbenzenesulfonamide (16288-77-0) → 2-((2-((3-aminophenyl)amino)-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide (1346447-83-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2: toluene-4-sulfonic acid / isopropyl alcohol / 5 h / 80 °C

3: hydrogen / platinum(IV) oxide / ethyl acetate / 2 h

With hydrogen; potassium carbonate; toluene-4-sulfonic acid; platinum(IV) oxide; In ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

upstream raw materials:

2-Nitrobenzenesulfonyl chloride

2-((2-amino-5-chloropyrimidin-4-yl)amino)-N-methylbenzenesulfonamide

2-amino-N-methylbenzenesulfonamide

N-methyl-2-nitrobenzenesulfonamide

Downstream raw materials:

N-(3-((5-chloro-4-((2-(N-methylsulfamoyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)acrylamide