N-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-(RS)-carbobenzyloxyalanine

Base Information

• Chemical Name: N-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-(RS)-carbobenzyloxyalanine
• CAS No.: 97998-66-8
• Molecular Formula: C₂₃H₂₇NO₆
• Molecular Weight: 413.47
• Mol file: 97998-66-8.mol

Synonyms:N-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-(RS)-carbobenzyloxyalanine

Chemical Property of N-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-(RS)-carbobenzyloxyalanine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-(RS)-carbobenzyloxyalanine

There total 3 articles about N-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-(RS)-carbobenzyloxyalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

D-homophenylalanine (943-73-7) → N-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-(RS)-carbobenzyloxyalanine (97998-66-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / HCl / 2 h / Heating

2: NaOH, H₂ / 5percent Pd/C / ethanol / 25 °C / 2172.02 - 4654.3 Torr

3: Et₃N / dimethylformamide / 2 h / 25 °C

With hydrogenchloride; sodium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00149a009

Reference yield:

L-(+)-α-amino-4-phenylbutyric acid ethyl ester hydrochloride (90891-21-7) → N-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-(RS)-carbobenzyloxyalanine (97998-66-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH, H₂ / 5percent Pd/C / ethanol / 25 °C / 2172.02 - 4654.3 Torr

2: Et₃N / dimethylformamide / 2 h / 25 °C

With sodium hydroxide; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00149a009

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) + N-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-(RS)-alanine (90988-18-4,122076-80-6) → N-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-(RS)-carbobenzyloxyalanine (97998-66-8)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 25 ℃; for 2h;

DOI:10.1021/jm00149a009

upstream raw materials:

benzyl chloroformate

N-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-(RS)-alanine

D-homophenylalanine

L-(+)-α-amino-4-phenylbutyric acid ethyl ester hydrochloride

Downstream raw materials:

N-<1(S)-(ethoxycarbonyl)-3-phenylpropyl>-(RS)-carbobenzyloxyalanine N-oxysuccinimidyl ester

Refernces