N-(4-methoxyphenyl)-1,4-dioxaspiro[4,5]decane-6-carboxamide

Base Information

• Chemical Name: N-(4-methoxyphenyl)-1,4-dioxaspiro[4,5]decane-6-carboxamide
• CAS No.: 204142-34-7
• Molecular Formula: C₁₆H₂₁NO₄
• Molecular Weight: 291.347
• Mol file: 204142-34-7.mol

Synonyms:N-(4-methoxyphenyl)-1,4-dioxaspiro[4,5]decane-6-carboxamide

Chemical Property of N-(4-methoxyphenyl)-1,4-dioxaspiro[4,5]decane-6-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-methoxyphenyl)-1,4-dioxaspiro[4,5]decane-6-carboxamide

There total 2 articles about N-(4-methoxyphenyl)-1,4-dioxaspiro[4,5]decane-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-aniline (104-94-9) + 1,4-dioxa-spiro[4.5]decane-6-carbonyl chloride (854133-07-6) → N-(4-methoxyphenyl)-1,4-dioxaspiro[4,5]decane-6-carboxamide (204142-34-7)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h; Yield given;

DOI:10.1080/00397919808005100

Reference yield:

1,4-dioxaspiro[4.5]decane-6-carboxylic acid (4746-93-4) → N-(4-methoxyphenyl)-1,4-dioxaspiro[4,5]decane-6-carboxamide (204142-34-7)

Guidance literature:

Multi-step reaction with 2 steps

1: (COCl)2 / dimethylformamide; CH₂Cl₂ / 2 h / 20 °C

2: Et₃N / CH₂Cl₂ / 2 h / 20 °C

With oxalyl dichloride; triethylamine; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1080/00397919808005100

Reference yield: 78.0%

N-(4-methoxyphenyl)-1,4-dioxaspiro[4,5]decane-6-carboxamide (204142-34-7) → N-(4-methoxyphenyl)-2-oxocyclohexanecarboxamide (27904-58-1)

Guidance literature:

With perchloric acid; In dichloromethane; at 20 ℃; for 0.333333h;

DOI:10.1080/00397919808005100

upstream raw materials:

4-methoxy-aniline

1,4-dioxa-spiro[4.5]decane-6-carbonyl chloride

1,4-dioxaspiro[4.5]decane-6-carboxylic acid

Downstream raw materials:

N-(4-methoxyphenyl)-2-oxocyclohexanecarboxamide