(2S-trans)-1-(methylsulfonyl)-4-<(tetrahydro-2H-pyran-2-yl)oxy>-2-pyrrolidinemethanol 4-methylbenzenesulfonate

Base Information

Chemical Name:(2S-trans)-1-(methylsulfonyl)-4-<(tetrahydro-2H-pyran-2-yl)oxy>-2-pyrrolidinemethanol 4-methylbenzenesulfonate
CAS No.:110450-58-3
Molecular Formula:C₁₈H₂₇NO₇S₂
Molecular Weight:433.547
Hs Code.:

Synonyms:(2S-trans)-1-(methylsulfonyl)-4-<(tetrahydro-2H-pyran-2-yl)oxy>-2-pyrrolidinemethanol 4-methylbenzenesulfonate

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Chemical Property of (2S-trans)-1-(methylsulfonyl)-4-<(tetrahydro-2H-pyran-2-yl)oxy>-2-pyrrolidinemethanol 4-methylbenzenesulfonate

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Technology Process of (2S-trans)-1-(methylsulfonyl)-4-<(tetrahydro-2H-pyran-2-yl)oxy>-2-pyrrolidinemethanol 4-methylbenzenesulfonate

There total 4 articles about (2S-trans)-1-(methylsulfonyl)-4-<(tetrahydro-2H-pyran-2-yl)oxy>-2-pyrrolidinemethanol 4-methylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 110-87-2
3,4-dihydro-2H-pyran

: 110450-57-2
(2S-trans)-4-hydroxy-1-(methylsulfonyl)-2-pyrrolidinemethanol α-(4-methylbenzenesulfonate)

: 110450-58-3
(2S-trans)-1-(methylsulfonyl)-4-<(tetrahydro-2H-pyran-2-yl)oxy>-2-pyrrolidinemethanol 4-methylbenzenesulfonate

Guidance literature:: With toluene-4-sulfonic acid;
DOI:10.1246/cl.1986.2061

Reference yield:

: 33996-30-4
trans-4-hydroxy-L-proline ethyl ester hydrochloride

: 110450-58-3
(2S-trans)-1-(methylsulfonyl)-4-<(tetrahydro-2H-pyran-2-yl)oxy>-2-pyrrolidinemethanol 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / anh. pyridine / a) 0 deg C, 6 h, b) RT, 15 h

2: 87 percent / LiAlH₄ / tetrahydrofuran / a) 0 deg C, 3 h, b) RT, 3 h

3: 100 percent / pyridine / a) -25 deg C, 15 h, b) 0 deg C, 4 h, c)RT, 1 h

4: 100 percent / pTsOH monohydrate / CH₂Cl₂ / 3 h / Ambient temperature

With pyridine; lithium aluminium tetrahydride; toluene-4-sulfonic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.42.481

Reference yield:

: 110005-19-1
(2S-trans)-4-hydroxy-1-(methylsulfonyl)-2-pyrrolidinemethanol

: 110450-58-3
(2S-trans)-1-(methylsulfonyl)-4-<(tetrahydro-2H-pyran-2-yl)oxy>-2-pyrrolidinemethanol 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / pyridine / a) -25 deg C, 15 h, b) 0 deg C, 4 h, c)RT, 1 h

2: 100 percent / pTsOH monohydrate / CH₂Cl₂ / 3 h / Ambient temperature

With pyridine; toluene-4-sulfonic acid; In dichloromethane;
DOI:10.1248/cpb.42.481