(2E,8Z,10E,16E,18E,20Z)-(S)-20-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxymethoxy-2-methyl-9-trimethylsilanyl-docosa-2,8,10,16,18,20-hexaenoic acid allyl ester

Base Information

Chemical Name:(2E,8Z,10E,16E,18E,20Z)-(S)-20-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxymethoxy-2-methyl-9-trimethylsilanyl-docosa-2,8,10,16,18,20-hexaenoic acid allyl ester
CAS No.:213122-60-2
Molecular Formula:C₄₈H₇₀O₅Si₂
Molecular Weight:783.252
Hs Code.:

(2E,8Z,10E,16E,18E,20Z)-(S)-20-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxymethoxy-2-methyl-9-trimethylsilanyl-docosa-2,8,10,16,18,20-hexaenoic acid allyl ester

Synonyms:(2E,8Z,10E,16E,18E,20Z)-(S)-20-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxymethoxy-2-methyl-9-trimethylsilanyl-docosa-2,8,10,16,18,20-hexaenoic acid allyl ester

Suppliers and Price of (2E,8Z,10E,16E,18E,20Z)-(S)-20-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxymethoxy-2-methyl-9-trimethylsilanyl-docosa-2,8,10,16,18,20-hexaenoic acid allyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2E,8Z,10E,16E,18E,20Z)-(S)-20-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxymethoxy-2-methyl-9-trimethylsilanyl-docosa-2,8,10,16,18,20-hexaenoic acid allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2E,8Z,10E,16E,18E,20Z)-(S)-20-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxymethoxy-2-methyl-9-trimethylsilanyl-docosa-2,8,10,16,18,20-hexaenoic acid allyl ester

There total 15 articles about (2E,8Z,10E,16E,18E,20Z)-(S)-20-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxymethoxy-2-methyl-9-trimethylsilanyl-docosa-2,8,10,16,18,20-hexaenoic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 129144-88-3
2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2(E)-butenal

: 213122-60-2
(2E,8Z,10E,16E,18E,20Z)-(S)-20-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxymethoxy-2-methyl-9-trimethylsilanyl-docosa-2,8,10,16,18,20-hexaenoic acid allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / tetrahydrofuran / -40 - 25 °C

2: 1.) BrCl₂CCCl₂Br, PPh₃ / 1.) CH₂Cl₂, 0 deg C, 2.) CH₃CN, 70 deg C

3: 84 percent / BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 - 23 °C

4: 1.) LiBF₄, H₂O, 2.) LiCl, DBU / 1.) CH₃CN, 2.) CH₃CN

With lithium tetrafluoroborate; n-butyllithium; 1,2-dibromo-1,1,2,2-tetrachloroethane; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; lithium chloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/ja980611f

Reference yield:

: 1501-26-4
methyl 4-(chlorocarbonyl)butyrate

: 213122-60-2
(2E,8Z,10E,16E,18E,20Z)-(S)-20-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxymethoxy-2-methyl-9-trimethylsilanyl-docosa-2,8,10,16,18,20-hexaenoic acid allyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 70 percent / AlCl₃

2: (-)-(α)-pinene, 9-BBN

3: i-Pr₂NEt / 25 °C

4: DIBAL-H / CH₂Cl₂ / -78 °C

5: p-TsOH / methanol

6: 1.) DIBAL-H, 2.) NIS, pyridine / 1.) Et₂O, 50 deg C

7: Pd(PPh₃)4, TlOH / tetrahydrofuran; H₂O

8: DMSO, (COCl)2 / CH₂Cl₂ / -78 °C

9: 84 percent / BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 - 23 °C

10: 1.) LiBF₄, H₂O, 2.) LiCl, DBU / 1.) CH₃CN, 2.) CH₃CN

With pyridine; N-iodo-succinimide; lithium tetrafluoroborate; 9-borabicyclo[3.3.1]nonane dimer; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; aluminium trichloride; TlOH; oxalyl dichloride; water; diisobutylaluminium hydride; 2,6,6-trimethylbicyclo[3.1.1]hept-2-ene; toluene-4-sulfonic acid; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water;
DOI:10.1021/ja980611f

Reference yield:

: 146983-30-4
4-{[(tert-butyldiphenylsilyl)oxy]methyl}-2(E),4(Z)-hexadienol

: 213122-60-2
(2E,8Z,10E,16E,18E,20Z)-(S)-20-(tert-Butyl-diphenyl-silanyloxymethyl)-7-methoxymethoxy-2-methyl-9-trimethylsilanyl-docosa-2,8,10,16,18,20-hexaenoic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) BrCl₂CCCl₂Br, PPh₃ / 1.) CH₂Cl₂, 0 deg C, 2.) CH₃CN, 70 deg C

2: 84 percent / BuLi / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 - 23 °C

3: 1.) LiBF₄, H₂O, 2.) LiCl, DBU / 1.) CH₃CN, 2.) CH₃CN

With lithium tetrafluoroborate; n-butyllithium; 1,2-dibromo-1,1,2,2-tetrachloroethane; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; lithium chloride; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1021/ja980611f