methyl 3-{5-tert-butyl-2-[2-(morpholin-4-yl)ethoxy]phenyl}-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate

Base Information

• Chemical Name: methyl 3-{5-tert-butyl-2-[2-(morpholin-4-yl)ethoxy]phenyl}-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate
• CAS No.: 1491155-55-5
• Molecular Formula: C₃₃H₃₈N₂O₆
• Molecular Weight: 558.675
• Mol file: 1491155-55-5.mol

Synonyms:methyl 3-{5-tert-butyl-2-[2-(morpholin-4-yl)ethoxy]phenyl}-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate

Chemical Property of methyl 3-{5-tert-butyl-2-[2-(morpholin-4-yl)ethoxy]phenyl}-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 3-{5-tert-butyl-2-[2-(morpholin-4-yl)ethoxy]phenyl}-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate

There total 7 articles about methyl 3-{5-tert-butyl-2-[2-(morpholin-4-yl)ethoxy]phenyl}-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

methyl 3-hydroxy-3-(4-methoxyphenyl)-2-oxindoline-7-carboxylate (1491155-34-0) + 4-[2-(4-tert-butylphenoxy)ethyl]morpholine → methyl 3-{5-tert-butyl-2-[2-(morpholin-4-yl)ethoxy]phenyl}-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate (1491155-55-5)

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; at 20 ℃; for 1.5h; Inert atmosphere; Cooling with ice;

Reference yield:

2-carbomethoxyaniline (134-20-3) → methyl 3-{5-tert-butyl-2-[2-(morpholin-4-yl)ethoxy]phenyl}-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate (1491155-55-5)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium sulfate; hydroxylamine hydrochloride; hydrogenchloride / water

2: sulfuric acid / Heating

3: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

4: trifluorormethanesulfonic acid / dichloromethane / 1.5 h / Cooling with ice; Inert atmosphere

With hydrogenchloride; trifluorormethanesulfonic acid; sulfuric acid; hydroxylamine hydrochloride; sodium sulfate; In tetrahydrofuran; dichloromethane; water; 3: |Grignard Reaction / 4: |Friedel-Crafts Acylation;

DOI:10.1016/j.ejmech.2013.08.030

Reference yield:

methyl 2-{[(hydroxyimino)acetyl]amino}benzoate (63016-87-5) → methyl 3-{5-tert-butyl-2-[2-(morpholin-4-yl)ethoxy]phenyl}-3-(4-methoxyphenyl)-2-oxoindoline-7-carboxylate (1491155-55-5)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid / Heating

2: tetrahydrofuran / 2 h / 20 °C / Inert atmosphere; Cooling with ice

3: trifluorormethanesulfonic acid / dichloromethane / 1.5 h / Cooling with ice; Inert atmosphere

With trifluorormethanesulfonic acid; sulfuric acid; In tetrahydrofuran; dichloromethane; 2: |Grignard Reaction / 3: |Friedel-Crafts Acylation;

DOI:10.1016/j.ejmech.2013.08.030

upstream raw materials:

4-methoxyphenyl magnesium bromide

2-carbomethoxyaniline

methyl 2-{[(hydroxyimino)acetyl]amino}benzoate

methyl 7-isatincarboxylate