2,4,6-Trimethoxypyrimidin-5-amine

Base Information

• Chemical Name: 2,4,6-Trimethoxypyrimidin-5-amine
• CAS No.: 16097-43-1
• Molecular Formula: C7H11 N3 O3
• Molecular Weight: 185.18054
• Hs Code.: 2933599090
• European Community (EC) Number: 893-177-6
• Mol file: 16097-43-1.mol

Synonyms:2,4,6-trimethoxypyrimidin-5-amine;16097-43-1;5-Pyrimidinamine, 2,4,6-trimethoxy- (9CI);SCHEMBL5765829;TRIMETHOXYPYRIMIDIN-5-AMINE;5-amino-2,4,6-trimethoxypyrimidine;EN300-8095979;Z1216842914

Chemical Property of 2,4,6-Trimethoxypyrimidin-5-amine

Chemical Property:

• PSA: 79.49000
• LogP: 0.66580
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 3
• Exact Mass: 185.08004122
• Heavy Atom Count: 13
• Complexity: 144

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=NC(=N1)OC)OC)N

Technology Process of 2,4,6-Trimethoxypyrimidin-5-amine

There total 6 articles about 2,4,6-Trimethoxypyrimidin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

5-nitro-2,4,6-trimethoxypyrimidine (83356-02-9) → 5-amino-2,4,6-trimethoxypyrimidine (16097-43-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 24h; under 1500.15 Torr;

Reference yield: 73.0%

sodium methylate (124-41-4) + 5-amino-2,4-dimethoxy-6-nitropyrimidine (131222-13-4) → 5-amino-2,4,6-trimethoxypyrimidine (16097-43-1)

Guidance literature:

Heating;

DOI:10.1007/BF00756435

Reference yield:

2-chloro-4,6-dimethoxy-5-nitro-pyrimidine (478010-54-7) → 5-amino-2,4,6-trimethoxypyrimidine (16097-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydride / mineral oil / 1 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 24 h / 1500.15 Torr

With palladium 10% on activated carbon; hydrogen; sodium hydride; In methanol; mineral oil;

upstream raw materials:

sodium methylate

5-amino-2,4-dimethoxy-6-nitropyrimidine

5-nitro-2,4,6-trimethoxypyrimidine

2-chloro-4,6-dimethoxy-5-nitro-pyrimidine