ethyl 3-(4-fluorophenyl)-2-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}propanoate

Base Information

• Chemical Name: ethyl 3-(4-fluorophenyl)-2-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}propanoate
• CAS No.: 1527480-50-7
• Molecular Formula: C₁₈H₂₀FNO₅S
• Molecular Weight: 381.425
• Mol file: 1527480-50-7.mol

Synonyms:ethyl 3-(4-fluorophenyl)-2-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}propanoate

Chemical Property of ethyl 3-(4-fluorophenyl)-2-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 3-(4-fluorophenyl)-2-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}propanoate

There total 2 articles about ethyl 3-(4-fluorophenyl)-2-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-fluorocinnamate (24393-50-8,136265-10-6,352-03-4) + bromamine T (41085-71-6) → ethyl 3-(4-fluorophenyl)-2-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}propanoate (1527480-50-7) + ethyl 3-(4-fluorophenyl)-2-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}propanoate

Guidance literature:

With potassium osmate; water; 4-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]-1-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]phthalazine; In tert-butyl alcohol; for 1h; Overall yield = 72 %; regioselective reaction;

DOI:10.1016/j.tetlet.2013.12.002

Reference yield:

chloroamine-T (127-65-1) → ethyl 3-(4-fluorophenyl)-2-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}propanoate (1527480-50-7) + ethyl 3-(4-fluorophenyl)-2-hydroxy-3-{[(4-methylphenyl)sulfonyl]amino}propanoate

Guidance literature:

Multi-step reaction with 3 steps

1: bromine / water / 1 h

2: sodium hydroxide / water / Cooling with ice

3: 4-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]-1-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]phthalazine; potassium osmate; water / tert-butyl alcohol / 1 h

With potassium osmate; water; bromine; 4-[(R)-[(2R,4R,5S)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]-1-[(R)-[(2R,4S,5R)-5-ethyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxy-4-quinolinyl)methoxy]phthalazine; sodium hydroxide; In water; tert-butyl alcohol;

DOI:10.1016/j.tetlet.2013.12.002

upstream raw materials:

ethyl 4-fluorocinnamate

bromamine T

chloroamine-T