2-{4-[2-tert-butyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolylamino]pentyl}-1,3-isoindolinedione

Base Information

Chemical Name:2-{4-[2-tert-butyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolylamino]pentyl}-1,3-isoindolinedione
CAS No.:861232-22-6
Molecular Formula:C₃₄H₃₄F₃N₃O₄
Molecular Weight:605.657
Hs Code.:

Synonyms:2-{4-[2-tert-butyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolylamino]pentyl}-1,3-isoindolinedione

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Chemical Property of 2-{4-[2-tert-butyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolylamino]pentyl}-1,3-isoindolinedione

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Technology Process of 2-{4-[2-tert-butyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolylamino]pentyl}-1,3-isoindolinedione

There total 6 articles about 2-{4-[2-tert-butyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolylamino]pentyl}-1,3-isoindolinedione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 861232-19-1
2-tert-butyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolinamine

: 59353-62-7
4-bromo-1-phthalimidopentane

: 861232-22-6
2-{4-[2-tert-butyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolylamino]pentyl}-1,3-isoindolinedione

Guidance literature:: With triethylamine; at 120 ℃; for 24h;
DOI:10.1016/j.bmc.2005.04.034

Reference yield:

: 5333-02-8
5,6-dimethoxy-8-nitroquinoline

: 861232-22-6
2-{4-[2-tert-butyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolylamino]pentyl}-1,3-isoindolinedione

Guidance literature:: Multi-step reaction with 6 steps

1: 65 percent / AgNO₃; ammonium persulfate; trimethylacetic acid / H₂SO₄ / acetonitrile / 0.25 h / 70 °C

2: 82 percent / HCl / 2 h / 100 °C

3: 100 percent / POCl₃ / 2 h / 80 °C

4: 78 percent / KOH / 12 h / 150 °C

5: 100 percent / H₂; Raney nickel / 0.75 h / 2327.17 Torr

6: 84 percent / Et₃N / 24 h / 120 °C

With hydrogenchloride; potassium hydroxide; ammonium persulfate; hydrogen; nickel; silver nitrate; triethylamine; trichlorophosphate; Trimethylacetic acid; sulfuric acid; In acetonitrile;
DOI:10.1016/j.bmc.2005.04.034

Reference yield:

: 861232-10-2
2-tert-butyl-6-methoxy-8-nitro-5-quinolinol

: 861232-22-6
2-{4-[2-tert-butyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolylamino]pentyl}-1,3-isoindolinedione

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / POCl₃ / 2 h / 80 °C

2: 78 percent / KOH / 12 h / 150 °C

3: 100 percent / H₂; Raney nickel / 0.75 h / 2327.17 Torr

4: 84 percent / Et₃N / 24 h / 120 °C

With potassium hydroxide; hydrogen; nickel; triethylamine; trichlorophosphate;
DOI:10.1016/j.bmc.2005.04.034