5333-02-8

Upstream product

• 7595-31-5 4-amino-5-nitroveratrol 
• 56-81-5 glycerol 
• 99069-17-7 4-Acetylamino-1,2-dimethoxy-5-nitrobenzene 
• 107-02-8 acrolein 
• 91-16-7 1,2-dimethoxybenzene 
• 85-81-4 6-methoxy-8-nitroquinoline 
• 3395-03-7 4,5-dimethoxy-1,2-dinitrobenzene 
• 67-56-1 methanol 
• 124-41-4 sodium methylate 
• 5347-15-9 5-bromo-6-methoxy-8-nitroquinoline 
• 64992-86-5 5-chloro-6-methoxy-8-nitro-quinoline 

Downstream Products

• 6938-02-9 8-amino-5,6-dimethoxyquinoline 
• 685092-60-8 2-cyclohexyl-5,6-dimethoxy-8-nitroquinoline 
• 17605-76-4 8-(5-isopropylamino-pentylamino)-quinoline-5,6-diol 
• 87321-06-0 5-hydroxy-6-desmethylprimaquine 
• 861232-22-6 2-{4-[2-tert-butyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolylamino]pentyl}-1,3-isoindolinedione 
• 861232-16-8 2-tert-butyl-6-methoxy-8-nitro-5-(3-trifluoromethylphenoxy)quinoline 
• 861232-19-1 2-tert-butyl-6-methoxy-5-(3-trifluoromethylphenoxy)-8-quinolinamine 
• 685092-78-8 2-[4-(2-cyclohexyl-5,6-dimethoxy-8-quinolinamino)pentyl]-1,3-isoindolinedione 
• 685092-69-7 2-cyclohexyl-5,6-dimethoxy-8-quinolinamine 

Relevant academic research and scientific papers

Metal-free synthesis of N-fused heterocyclic iodides via C-H functionalization mediated by tert-butylhydroperoxide

Direct, regioselective and metal-free synthesis of fused N-heterocyclic iodides is reported. This regioselective C-H functionalization is mediated by tert-butylhydroperoxide (TBHP), via dual activation of molecular iodine and a heterocyclic substrate, resulting in the in situ generation of electrophilic iodine species (I+), and free radical(s) tBuO? or tBuOO?, driving the iodination reaction.

HEAT SHOCK PROTEIN 90 INHIBITORS, METHODS OF PREPARING SAME, AND METHODS FOR THEIR USE

Novel classes of molecular chaperone Heat shock protein 90 (Hsp90) inhibitors are disclosed. These compounds are useful in treating and preventing cancer and other Hsp90-related diseases and conditions, such as inflammation and neurodegenerative disorders. Methods of treating and preventing cancer and other Hsp90 related diseases and conditions are disclosed that include administering to the subject a therapeutically effective amount of an Hsp90 inhibitor. Methods of preparing the novel Hsp90 inhibitors are also provided.

8-Aminoquinolines as anticoccidials - I

The proposed ring metabolites of the 8-aminoquinoline antimalarial, pentaquine, 1, have been synthesised and their biological activity as anticoccidial agents investigated in vivo. Several analogues in which this metabolic pathway had been blocked were also synthesised and their anticoccidial activity measured.

Antimalarials. 13. 5-Alkoxy Analogues of 4-Methylprimaquine

A series of nuclear and side-chain analogues of 4-methylprimaquine incorporating an alkoxy group in 5-position of the quinoline nucleus has been prepared.The compounds were tested for suppresive antimalarial activity against Plasmodium berghei in mice and for radical curative antimalarial activity against Plasmodium cynomolgi in the rhesus monkey.Although the toxicity problems characteristic of the 8-aminoquinolines were not overcome, several of the compounds, suprisingly, were highly effective as both blood and tissue schizonticidal agents.

Process for production of 8-NHR quinolines

An improved process for producing 8-NHR quinolines from 8-aminoquinolines disclosed. The process comprises reacting 8-aminoquinolines with a substituted alkyl halide in the presence of an amine having a boiling point of 80°-90° C. The amine functions as an acid acceptor whereby the amine salt formed may be efficiently separated from the 8-NHR quinoline formed without expensive or time consuming purification steps. The reaction may be carried out in the presence of a solvent such as an alcohol.