2-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazole-3-sulfinylmethyl}-benzoic acid methyl ester

Base Information

Chemical Name:2-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazole-3-sulfinylmethyl}-benzoic acid methyl ester
CAS No.:146885-29-2
Molecular Formula:C₂₉H₂₉N₇O₃S
Molecular Weight:555.66
Hs Code.:

Synonyms:2-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazole-3-sulfinylmethyl}-benzoic acid methyl ester

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Chemical Property of 2-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazole-3-sulfinylmethyl}-benzoic acid methyl ester

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Technology Process of 2-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazole-3-sulfinylmethyl}-benzoic acid methyl ester

There total 7 articles about 2-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazole-3-sulfinylmethyl}-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 134460-87-0
3-n-Butyl-5-[2-(carbomethoxy)benzylthio]-4-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]-4H-1,2,4-triazole

: 146885-29-2
2-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazole-3-sulfinylmethyl}-benzoic acid methyl ester

Guidance literature:: With dihydrogen peroxide; In acetic acid; for 17.5h; Ambient temperature;
DOI:10.1021/jm00057a009

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 146885-29-2
2-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazole-3-sulfinylmethyl}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 68 percent / lithium azide / dimethylsulfoxide / 1 h / Ambient temperature

2: triphenylphosphine / 5.5 h / Ambient temperature

3: hydrazine hydrate / tetrahydrofuran / 0.17 h

4: 64 percent / 2-methoxy-ethanol / 4 h / Heating

5: 76 percent / N,N-diisopropylethylamine / 2-methoxy-ethanol / 3.5 h / Ambient temperature

6: 54 percent / trimethyltin azide / toluene / 24 h / Heating

7: 69 percent / 30percent aq. H₂O₂ / acetic acid / 17.5 h / Ambient temperature

With lithium azide; trimethyltin azide; dihydrogen peroxide; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 2-methoxy-ethanol; acetic acid; dimethyl sulfoxide; toluene;
DOI:10.1021/jm00057a009

Reference yield:

: 133690-91-2
4'-(azidomethyl)[1,1'-biphenyl]-2-carbonitrile

: 146885-29-2
2-{5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4H-[1,2,4]triazole-3-sulfinylmethyl}-benzoic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: triphenylphosphine / 5.5 h / Ambient temperature

2: hydrazine hydrate / tetrahydrofuran / 0.17 h

3: 64 percent / 2-methoxy-ethanol / 4 h / Heating

4: 76 percent / N,N-diisopropylethylamine / 2-methoxy-ethanol / 3.5 h / Ambient temperature

5: 54 percent / trimethyltin azide / toluene / 24 h / Heating

6: 69 percent / 30percent aq. H₂O₂ / acetic acid / 17.5 h / Ambient temperature

With trimethyltin azide; dihydrogen peroxide; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; 2-methoxy-ethanol; acetic acid; toluene;
DOI:10.1021/jm00057a009