(2S)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-(4-t-butylphenylphenyl)propyl pivalate

Base Information

Chemical Name:(2S)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-(4-t-butylphenylphenyl)propyl pivalate
CAS No.:1003002-87-6
Molecular Formula:C₂₃H₃₆O₄
Molecular Weight:376.536
Hs Code.:

Synonyms:(2S)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-(4-t-butylphenylphenyl)propyl pivalate

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Chemical Property of (2S)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-(4-t-butylphenylphenyl)propyl pivalate

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Technology Process of (2S)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-(4-t-butylphenylphenyl)propyl pivalate

There total 4 articles about (2S)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-(4-t-butylphenylphenyl)propyl pivalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1003002-78-5
(2S)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-(4-t-butylphenyl)-1-propanol

: 3282-30-2
pivaloyl chloride

: 1003002-87-6
(2S)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-(4-t-butylphenylphenyl)propyl pivalate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jm701049p

Reference yield:

: 18880-00-7
1-(bromomethyl)-4-(1,1-dimethylethyl)benzene

: 1003002-87-6
(2S)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-(4-t-butylphenylphenyl)propyl pivalate

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hexamethyldisilazane; N,N,N,N,N,N-hexamethylphosphoric triamide / tetrahydrofuran

2: lithium aluminium tetrahydride / tetrahydrofuran

3: toluene-4-sulfonic acid

4: pyridine

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; lithium aluminium tetrahydride; toluene-4-sulfonic acid; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2014.04.054

Reference yield:

: C₁₅H₂₀O₅

: 1003002-87-6
(2S)-2-[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]-3-(4-t-butylphenylphenyl)propyl pivalate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran

2: toluene-4-sulfonic acid

3: pyridine

With pyridine; lithium aluminium tetrahydride; toluene-4-sulfonic acid; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2014.04.054