2-{[(4-fluorophenyl)methyl]oxy}-N-3-pyridinyl-5-(trifluoromethyl)benzamide

Base Information

Chemical Name:2-{[(4-fluorophenyl)methyl]oxy}-N-3-pyridinyl-5-(trifluoromethyl)benzamide
CAS No.:1285515-71-0
Molecular Formula:C₂₀H₁₄F₄N₂O₂
Molecular Weight:390.337
Hs Code.:

Synonyms:2-{[(4-fluorophenyl)methyl]oxy}-N-3-pyridinyl-5-(trifluoromethyl)benzamide

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Chemical Property of 2-{[(4-fluorophenyl)methyl]oxy}-N-3-pyridinyl-5-(trifluoromethyl)benzamide

Chemical Property:

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Technology Process of 2-{[(4-fluorophenyl)methyl]oxy}-N-3-pyridinyl-5-(trifluoromethyl)benzamide

There total 5 articles about 2-{[(4-fluorophenyl)methyl]oxy}-N-3-pyridinyl-5-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.4%

: 462-08-8
pyridin-3-ylamine

: 1285517-55-6
2-{[(4-fluorophenyl)methyl]oxy}-5-(trifluoromethyl)benzoic acid

: 1285515-71-0
2-{[(4-fluorophenyl)methyl]oxy}-N-3-pyridinyl-5-(trifluoromethyl)benzamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2017.07.052

Reference yield:

: 79427-88-6
2-hydroxy-5-(trifluoromethyl)benzoic acid

: 1285515-71-0
2-{[(4-fluorophenyl)methyl]oxy}-N-3-pyridinyl-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / Reflux

2.1: water; lithium hydroxide / tetrahydrofuran / 2 h / Reflux

2.2: pH 1

3.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 - 70 °C

With water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1285517-52-3
(4-fluorophenyl)methyl 2-{[(4-fluorophenyl)methyl]oxy}-5-(trifluoromethyl)benzoate

: 1285515-71-0
2-{[(4-fluorophenyl)methyl]oxy}-N-3-pyridinyl-5-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 2 h / Reflux

1.2: pH 1

2.1: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 - 70 °C

With water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;