4,6-Dimethoxypyrimidin-5-amine

Base Information

• Chemical Name: 4,6-Dimethoxypyrimidin-5-amine
• CAS No.: 15846-15-8
• Molecular Formula: C₆H₉N₃O₂
• Molecular Weight: 155.156
• Hs Code.: 2933599090
• DSSTox Substance ID: DTXSID90384725
• Nikkaji Number: J779.559I
• Wikidata: Q72468526
• Mol file: 15846-15-8.mol

Synonyms:4,6-dimethoxypyrimidin-5-amine;15846-15-8;5-Pyrimidinamine, 4,6-dimethoxy-;5-Pyrimidinamine, 4,6-dimethoxy-;AMY131;SCHEMBL2900733;4,6-dimethoxy-5-pyrimidinamine;5-amino-4,6-dimethoxypyrimidin;DTXSID90384725;SYIABKXOJVXKDU-UHFFFAOYSA-N;MFCD00194013;AKOS003621198;SB57750;TS-00076;CS-0097886;FT-0750758;EN300-1295908;A852024

Chemical Property of 4,6-Dimethoxypyrimidin-5-amine

Chemical Property:

• Vapor Pressure: 0.00142mmHg at 25°C
• Melting Point: 95-96℃ (ligroine )
• Refractive Index: 1.547
• Boiling Point: 296.6ºC at 760 mmHg
• Flash Point: 133.2ºC
• PSA: 70.26000
• Density: 1.229g/cm3
• LogP: 0.65720
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 155.069476538
• Heavy Atom Count: 11
• Complexity: 110

Purity/Quality:

97% ^*data from raw suppliers

4,6-Dimethoxypyrimidin-5-amine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=NC=N1)OC)N

Technology Process of 4,6-Dimethoxypyrimidin-5-amine

There total 2 articles about 4,6-Dimethoxypyrimidin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

5-nitro-4,6-dimethoxypyrimidine (15846-14-7) → 4,6-dimethoxypyrimidin-5-ylamine (15846-15-8)

Guidance literature:

With potassium hydroxide; sodium dithionite; In methanol; water;

Reference yield:

→ 4,6-dimethoxypyrimidin-5-ylamine (15846-15-8)

Guidance literature:

5-Nitro-4,6-dimethoxy-pyrimidin (X), H2,Raney-Ni;

Reference yield:

resin bound 3-[4-(3,5-dichloropyrid-4-ylcarboxamido)phenyl]-2-diazopropanoic acid + 4,6-dimethoxypyrimidin-5-ylamine (15846-15-8) → 3-[4-(3,5-dichloropyrid-4-ylcarboxamido)phenyl]-2-(4,6dimethoxypyrimidin-5-ylamino)propanoic acid

Guidance literature:

Paramax Wang resin

upstream raw materials:

5-nitro-4,6-dimethoxypyrimidine