(3R)-benzyl 3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)pyrrolidine-1-carboxylate

Base Information

Chemical Name:(3R)-benzyl 3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)pyrrolidine-1-carboxylate
CAS No.:1315591-91-3
Molecular Formula:C₁₉H₂₇NO₅
Molecular Weight:349.427
Hs Code.:

Synonyms:(3R)-benzyl 3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)pyrrolidine-1-carboxylate

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Chemical Property of (3R)-benzyl 3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)pyrrolidine-1-carboxylate

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Technology Process of (3R)-benzyl 3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)pyrrolidine-1-carboxylate

There total 2 articles about (3R)-benzyl 3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 17739-45-6,59146-56-4
2-(2-bromoethoxy)tetrahydropyran

: 100858-33-1
(3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester

: 1315591-91-3
(3R)-benzyl 3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)pyrrolidine-1-carboxylate

Guidance literature:: (3R)-3-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 1h;

2-(2-bromoethoxy)tetrahydropyran; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm201702g

Reference yield:

: 110-87-2
3,4-dihydro-2H-pyran

: 1315591-91-3
(3R)-benzyl 3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid

2: sodium hydride / N,N-dimethyl-formamide

With sodium hydride; toluene-4-sulfonic acid; In N,N-dimethyl-formamide;

Reference yield:

: 1315591-91-3
(3R)-benzyl 3-(2-((tetrahydro-2H-pyran-2-yl)oxy)ethoxy)pyrrolidine-1-carboxylate

: 1315586-11-8
(R)-2-(3-(2-hydroxyethoxy)pyrrolidin-1-yl)-N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)pyrrolo[2,1-f][1,2,4]triazin-2-yl)thio)phenyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / Inert atmosphere

2: hydrogenchloride; water / tetrahydrofuran / 4 h / 0 °C

3: N-ethyl-N,N-diisopropylamine; potassium iodide / N,N-dimethyl-formamide / 50 °C

With hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; N-ethyl-N,N-diisopropylamine; potassium iodide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm201702g