tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate

Base Information

Chemical Name:tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate
CAS No.:1331869-22-7
Molecular Formula:C₂₁H₃₂O₇S
Molecular Weight:428.547
Hs Code.:

Synonyms:tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate

Suppliers and Price of tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate

There total 8 articles about tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1173184-84-3
tert-butyl 2-[(4R,6R)-6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl]acetate

: 98-59-9
p-toluenesulfonyl chloride

: 1331869-22-7
tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;
DOI:10.1016/j.tet.2011.05.109

Reference yield:

: C₁₈H₂₈O₅

: 1331869-22-7
tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / acetone / 4 h / 20 °C

2: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr

3: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C

With dmap; 20% palladium hydroxide on carbon; hydrogen; toluene-4-sulfonic acid; triethylamine; In dichloromethane; ethyl acetate; acetone;
DOI:10.1016/j.tet.2011.05.109

Reference yield:

: 1331869-20-5
(R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate

: 1331869-22-7
tert-butyl 2-((4R,6R)-2,2-dimethyl-6-(2-(tosyloxy)ethyl)-1,3-dioxan-4-yl)acetate

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3.5 h / 0 - 20 °C

2: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 10 h / -80 °C

3: toluene-4-sulfonic acid / acetone / 4 h / 20 °C

4: 20% palladium hydroxide on carbon; hydrogen / ethyl acetate / 24 h / 60 °C / 760.05 Torr

5: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C

With dmap; sodium tetrahydroborate; 20% palladium hydroxide on carbon; diethyl methoxy borane; tetrabutyl ammonium fluoride; hydrogen; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; acetone;
DOI:10.1016/j.tet.2011.05.109