(R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate

Base Information

Chemical Name:(R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate
CAS No.:1331869-20-5
Molecular Formula:C₂₄H₄₀O₅Si
Molecular Weight:436.664
Hs Code.:

Synonyms:(R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate

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Technology Process of (R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate

There total 6 articles about (R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1347738-07-1
(R)-N,N-diallyl-5-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)pentanethioamide

: 1207973-75-8
lithium tert-butyl acetate

: 1331869-20-5
(R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate

Guidance literature:: (R)-N,N-diallyl-5-(benzyloxy)-3-((tert-butyldimethylsilyl)oxy)pentanethioamide; With methyl trifluoromethanesulfonate; In diethyl ether; at 0 - 20 ℃; for 4.5h; Inert atmosphere;

lithium tert-butyl acetate; In diethyl ether; at -78 ℃; for 3h; Inert atmosphere;

Reference yield:

: CF₃O₃S^(1-)*C₂₅H₄₂NO₂SSi⁽¹⁺⁾

: 1207973-75-8
lithium tert-butyl acetate

: 1331869-20-5
(R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate

Guidance literature:: CF₃O₃S^(1-)*C₂₅H₄₂NO₂SSi⁽¹⁺⁾; lithium tert-butyl acetate; In tetrahydrofuran; diethyl ether; at -78 ℃;

With silica gel; In tetrahydrofuran; diethyl ether; at -78 ℃;
DOI:10.1016/j.tet.2011.05.109

Reference yield:

: 1331869-16-9
(R)-N,N-diallyl-5-(benzyloxy)-3-hydroxypentanethioamide

: 1331869-20-5
(R)-tert-butyl 7-(benzyloxy)-5-((tert-butyldimethylsilyl)oxy)-3-oxoheptanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,6-dimethylpyridine / dichloromethane / 3 h / 0 - 20 °C

2.1: diethyl ether / 4.5 h / 0 - 20 °C

3.1: tetrahydrofuran; diethyl ether / -78 °C

3.2: -78 °C

With 2,6-dimethylpyridine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1016/j.tet.2011.05.109