L-Arg-L-Asp

Base Information

• Chemical Name: L-Arg-L-Asp
• CAS No.: 15706-88-4
• Molecular Formula: C10H19 N5 O5
• Molecular Weight: 289.291
• Hs Code.: 2925290090
• DSSTox Substance ID: DTXSID10431265
• Mol file: 15706-88-4.mol

Synonyms:Arg-Asp;2-[[2-amino-5-(diaminomethylideneamino)pentanoyl]amino]butanedioic acid;L-Arg-L-Asp;Arginyl-Aspartate;H-Arg-D-Asp-OH;SCHEMBL15995487;DTXSID10431265;CHEBI:179437;SIFXMYAHXJGAFC-UHFFFAOYSA-N;RD;J-009375;7-HYDROXY-1,2,3,4-TETRAHYDRO-NAPHTHALENE-2-CARBOXYLICACID

Chemical Property of L-Arg-L-Asp

Chemical Property:

• PSA: 228.92000
• LogP: -0.00590
• Storage Temp.: -15°C
• XLogP3: -5.3
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 9
• Exact Mass: 289.13861872
• Heavy Atom Count: 20
• Complexity: 394

Purity/Quality:

98%Min ^*data from raw suppliers

Arg-Asp-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(CC(C(=O)NC(CC(=O)O)C(=O)O)N)CN=C(N)N
• Recent ClinicalTrials: APG-2575 Monotherapy or in Combination With Lenalidomide/DXMS in Subjects With Relapsed or Refractory Multiple Myeloma

Technology Process of L-Arg-L-Asp

There total 10 articles about L-Arg-L-Asp which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-Aspartic acid (56-84-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) + L-arginine (74-79-3,25212-18-4) → Arg-Asp (15706-88-4) + Nα-L-arginyl-L-arginine (15483-27-9,455-64-1) + arginyl-arginyl-arginine (6418-87-7) + C22H41N13O5 + C28H53N17O7 + C32H56N18O9 + C64H80N26O25 + C60H77N25O23 + C56H74N24O21 + C52H71N23O19 + C48H68N22O17 + C44H65N21O15 + C40H62N20O13 + C36H59N19O11 + C24H37N11O10 + C28H40N12O12 + C32H43N13O14 + C36H46N14O16 + C40H49N15O18 + C44H52N16O20 + C8H10N2O5 + C12H13N3O7 + C16H16N4O9 + C54H50N16O25 + C50H47N15O23 + C46H44N14O21 + C42H41N13O19 + C38H38N12O17 + C34H35N11O15 + C30H32N10O13 + C26H29N9O11 + C22H26N8O9 + C18H23N7O7 + C14H20N6O5 + C10H17N5O3 + C16H29N9O5 + C20H32N10O7 + C24H35N11O9 + C28H38N12O11 + C32H41N13O13 + C36H44N14O15 + C40H47N15O17 + C44H50N16O19 + C48H53N17O21 + C52H56N18O23 + C56H59N19O25 + C60H62N20O27 + C64H65N21O29 + C68H68N22O31 + C72H71N23O33 + C76H74N24O35 + C90H92N30O39 + C86H89N29O37 + C82H86N28O35 + C78H83N27O33 + C74H80N26O31 + C70H77N25O29 + C66H74N24O27 + C62H71N23O25 + C58H68N22O23 + C54H65N21O21 + C50H62N20O19 + C46H59N19O17 + C42H56N18O15 + C38H53N17O13 + C34H50N16O11 + C30H47N15O9 + C26H44N14O7

Guidance literature:

With sulfuric acid; at 140 ℃; for 300h; Time; Temperature;

DOI:10.1007/s11172-012-0060-3

Reference yield:

N5-[imino(nitroamino)methyl]-N2-[(phenylmethoxy)carbonyl]-L-ornithine (2304-98-5) → Arg-Asp (15706-88-4)

Guidance literature:

Multi-step reaction with 3 steps

1: THF; dicyclohexylcarbodiimide; triethylamine / Reagens 4: CHCl₃

2: acetone; aqueous NaOH

3: palladium; aqueous methanol. acetic acid / Hydrogenation

With tetrahydrofuran; sodium hydroxide; palladium; acetic acid; triethylamine; dicyclohexyl-carbodiimide; acetone;

Reference yield:

N-(Nα-benzyloxycarbonyl-Nω-nitro-L-arginyl)-L-aspartic acid dibenzyl ester (122517-23-1) → Arg-Asp (15706-88-4)

Guidance literature:

With palladium; acetic acid; Hydrogenation;

upstream raw materials:

N-(N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl)-L-aspartic acid

N-(N^α-benzyloxycarbonyl-N^ω-nitro-L-arginyl)-L-aspartic acid dibenzyl ester

N-(N^α,N^δ,N^ω-tris-benzyloxycarbonyl-L-arginyl)-L-aspartic acid dibenzyl ester

N^α,N^δ,N^ω-tris(benzyloxycarbonyl)-L-arginine

Downstream raw materials:

L-Aspartic acid

L-arginine

Refernces

• 1、 Kino, Kuniki,Kotanaka, Yoichi,Arai, Toshinobu,Yagasaki, Makoto. "A novel L-amino acid ligase from Bacillus subtilis NBRC3134, a microorganism producing peptide-antibiotic rhizocticin". body text. p. 901 - 907. Retrieved 2009/11/30.