2-benzyl-5-ethylidene-6-oxo-4-vinyl-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid isobutyl-amide

Base Information

Chemical Name:2-benzyl-5-ethylidene-6-oxo-4-vinyl-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid isobutyl-amide
CAS No.:933996-05-5
Molecular Formula:C₂₁H₂₆N₂O₂
Molecular Weight:338.45
Hs Code.:

Synonyms:2-benzyl-5-ethylidene-6-oxo-4-vinyl-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid isobutyl-amide

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Chemical Property of 2-benzyl-5-ethylidene-6-oxo-4-vinyl-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid isobutyl-amide

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Technology Process of 2-benzyl-5-ethylidene-6-oxo-4-vinyl-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid isobutyl-amide

There total 2 articles about 2-benzyl-5-ethylidene-6-oxo-4-vinyl-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid isobutyl-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-benzyl-5-ethylidene-6-oxo-4-vinyl-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid

: 78-81-9
isobutylamine

: 933996-05-5
2-benzyl-5-ethylidene-6-oxo-4-vinyl-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid isobutyl-amide

Guidance literature:: With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.3987/com-06-s(w)36

Reference yield:

: 924906-47-8
2-benzyl-5-ethylidene-6-oxo-4-vinyl-1,2,5,6-tetrahydropyridine-2-carboxylic acid methyl ester

: 933996-05-5
2-benzyl-5-ethylidene-6-oxo-4-vinyl-1,2,5,6-tetrahydro-pyridine-2-carboxylic acid isobutyl-amide

Guidance literature:: Multi-step reaction with 2 steps

1: LiOH*H₂O / tetrahydrofuran; H₂O / 0.08 h / 20 °C

2: 0.178 g / 1-hydroxybenzotriazole; 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide*HCl; 4-dimethylaminopyridine / CH₂Cl₂ / 20 °C

With dmap; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; water;
DOI:10.3987/com-06-s(w)36