3-[(4aR,6S,8aS)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-4-chlorobenzonitrile

Base Information

Chemical Name:3-[(4aR,6S,8aS)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-4-chlorobenzonitrile
CAS No.:1613393-73-9
Molecular Formula:C₁₅H₁₆ClN₃OS
Molecular Weight:321.831
Hs Code.:

Synonyms:3-[(4aR,6S,8aS)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-4-chlorobenzonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-[(4aR,6S,8aS)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-4-chlorobenzonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-[(4aR,6S,8aS)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-4-chlorobenzonitrile

There total 8 articles about 3-[(4aR,6S,8aS)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-4-chlorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1613393-77-3
N-[(4aR,6S,8aS)-8a-(2-chloro-5-cyanophenyl)-6-methyl-4,4a,5,6,8,8a-hexahydropyrano[3,4-d][1,3]thiazin-2-yl]benzamide

: 1613393-73-9
3-[(4aR,6S,8aS)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-4-chlorobenzonitrile

Guidance literature:: With hydrazine hydrate; In ethanol; at 20 ℃; for 1h;

Reference yield:

: 1613393-76-2
N-{[(3S,4R,6S)-3-(2-chloro-5-cyanophenyl)-4-(hydroxymethyl)-6-methyltetrahydro-2H-pyran-3-yl]carbamothioyl}benzamide

: 1613393-73-9
3-[(4aR,6S,8aS)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-4-chlorobenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; trifluoromethylsulfonic anhydride / dichloromethane / 3 h / -78 - 0 °C

2: hydrazine hydrate / ethanol / 1 h / 20 °C

With pyridine; trifluoromethylsulfonic anhydride; hydrazine hydrate; In ethanol; dichloromethane;

Reference yield:

: 1613393-74-0
4-chloro-3-[(3aR,5S,7aS)-5-methyltetrahydro-1H-pyrano[3,4-c][1,2]oxazol-7a(7H)-yl]benzonitrile

: 1613393-73-9
3-[(4aR,6S,8aS)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-4-chlorobenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: zinc; acetic acid / 1 h / 20 °C

2: dichloromethane / 22 h / 20 °C

3: pyridine; trifluoromethylsulfonic anhydride / dichloromethane / 3 h / -78 - 0 °C

4: hydrazine hydrate / ethanol / 1 h / 20 °C

With pyridine; trifluoromethylsulfonic anhydride; hydrazine hydrate; acetic acid; zinc; In ethanol; dichloromethane;